Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 1876237..1876857 Replicon chromosome
Accession NZ_CP090722
Organism Burkholderia multivorans strain 2014Y70522077

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3KJN2
Locus tag L0Z19_RS24070 Protein ID WP_012217495.1
Coordinates 1876237..1876554 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID B9B269
Locus tag L0Z19_RS24075 Protein ID WP_006398012.1
Coordinates 1876558..1876857 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z19_RS24060 (L0Z19_24060) 1872770..1874203 - 1434 WP_006404214.1 aldehyde dehydrogenase family protein -
L0Z19_RS24065 (L0Z19_24065) 1874232..1875872 - 1641 WP_006398015.1 acetolactate synthase large subunit -
L0Z19_RS24070 (L0Z19_24070) 1876237..1876554 + 318 WP_012217495.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0Z19_RS24075 (L0Z19_24075) 1876558..1876857 + 300 WP_006398012.1 putative addiction module antidote protein Antitoxin
L0Z19_RS24080 (L0Z19_24080) 1876892..1878178 - 1287 WP_249461891.1 DUF445 domain-containing protein -
L0Z19_RS24085 (L0Z19_24085) 1878293..1879513 - 1221 WP_249461894.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
L0Z19_RS24090 (L0Z19_24090) 1879503..1879829 - 327 WP_006404219.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
L0Z19_RS24095 (L0Z19_24095) 1879847..1880335 - 489 WP_006398008.1 anthranilate 1,2-dioxygenase small subunit AndAd -
L0Z19_RS24100 (L0Z19_24100) 1880350..1881621 - 1272 WP_249461897.1 anthranilate 1,2-dioxygenase large subunit AndAc -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-102)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.94 Da        Isoelectric Point: 10.2349

>T231719 WP_012217495.1 NZ_CP090722:1876237-1876554 [Burkholderia multivorans]
MPYLAPTFSIRTTAVFDAWFAGLQDRTAKRRIQARIDRLSMGNLGNWKSVGSPVYEMRIDHGPGYRVYFVRRRTIWVVLL
CGGDKSTQRDDIRAAHAMLEHLDLE

Download         Length: 318 bp

>T231719 NZ_CP126945:77203-77508 [Escherichia coli O1:K1:H7]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGTTGTCAGATAAGGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAGGAAGTG
GCTGATCTCAGCCACCGAGAAAATGACATCAAAAATGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10605.00 Da        Isoelectric Point: 6.6381

>AT231719 WP_006398012.1 NZ_CP090722:1876558-1876857 [Burkholderia multivorans]
MSKISTRPWDSAEHLKTDDDMAEYFEACLQEGGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp

>AT231719 NZ_CP126945:76983-77201 [Escherichia coli O1:K1:H7]
ATGAAGCAGCGCATTACAGTCACCGTCGACAGTGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGGCT
GGTAAGCACCACCCTGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCAGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KJN2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3KTI5

References