Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
| Location | 918483..920230 | Replicon | chromosome |
| Accession | NZ_CP090722 | ||
| Organism | Burkholderia multivorans strain 2014Y70522077 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | B9BHC0 |
| Locus tag | L0Z19_RS19910 | Protein ID | WP_006403210.1 |
| Coordinates | 918483..919379 (+) | Length | 299 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | B9AZJ2 |
| Locus tag | L0Z19_RS19915 | Protein ID | WP_006396780.1 |
| Coordinates | 919376..920230 (+) | Length | 285 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L0Z19_RS19880 (L0Z19_19880) | 913882..914961 | - | 1080 | WP_249462492.1 | porin | - |
| L0Z19_RS19885 (L0Z19_19885) | 915398..915715 | + | 318 | WP_053298416.1 | non-heme iron oxygenase ferredoxin subunit | - |
| L0Z19_RS19890 (L0Z19_19890) | 915717..916028 | + | 312 | WP_053298417.1 | hypothetical protein | - |
| L0Z19_RS19895 (L0Z19_19895) | 916076..917146 | + | 1071 | WP_006413805.1 | aromatic ring-hydroxylating dioxygenase subunit alpha | - |
| L0Z19_RS19900 (L0Z19_19900) | 917139..917909 | + | 771 | WP_006413827.1 | SDR family oxidoreductase | - |
| L0Z19_RS19905 (L0Z19_19905) | 917937..918464 | + | 528 | WP_006396778.1 | cupin domain-containing protein | - |
| L0Z19_RS19910 (L0Z19_19910) | 918483..919379 | + | 897 | WP_006403210.1 | alpha/beta fold hydrolase | Toxin |
| L0Z19_RS19915 (L0Z19_19915) | 919376..920230 | + | 855 | WP_006396780.1 | IclR family transcriptional regulator | Antitoxin |
| L0Z19_RS19920 (L0Z19_19920) | 920227..921024 | + | 798 | WP_006396781.1 | SDR family oxidoreductase | - |
| L0Z19_RS19925 (L0Z19_19925) | 921017..922684 | + | 1668 | WP_053298420.1 | thiamine pyrophosphate-binding protein | - |
| L0Z19_RS19930 (L0Z19_19930) | 922677..923507 | + | 831 | WP_006403212.1 | aspartate dehydrogenase | - |
| L0Z19_RS19935 (L0Z19_19935) | 923569..925059 | + | 1491 | WP_006403213.1 | aldehyde dehydrogenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 299 a.a. Molecular weight: 30544.80 Da Isoelectric Point: 8.0446
>T231717 WP_006403210.1 NZ_CP090722:918483-919379 [Burkholderia multivorans]
MSVVDKRERDRTAAFATLLERFPEQRCAAGAAGTIGYREAGAQQAGAALPVVLLHGIGSGAASWVRQLDALGASRRVLAW
DAPGYGASTPVHGASPSAVDYAASLDAWLDALGIARCVLVGHSLGAIVAGGMVRVKPERIAGLLLISPAGGYGSAPAETR
ASRRDARLAMLAELGPAGLAAQRSGNMLSGFATEDARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAGVGLQVIPQAGHAGYVEAPDVYSALIDAFCRQCDIERRAA
MSVVDKRERDRTAAFATLLERFPEQRCAAGAAGTIGYREAGAQQAGAALPVVLLHGIGSGAASWVRQLDALGASRRVLAW
DAPGYGASTPVHGASPSAVDYAASLDAWLDALGIARCVLVGHSLGAIVAGGMVRVKPERIAGLLLISPAGGYGSAPAETR
ASRRDARLAMLAELGPAGLAAQRSGNMLSGFATEDARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAGVGLQVIPQAGHAGYVEAPDVYSALIDAFCRQCDIERRAA
Download Length: 897 bp
>T231717 NZ_CP126945:c67952-67536 [Escherichia coli O1:K1:H7]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA
Antitoxin
Download Length: 285 a.a. Molecular weight: 31176.75 Da Isoelectric Point: 6.6558
>AT231717 WP_006396780.1 NZ_CP090722:919376-920230 [Burkholderia multivorans]
MSEPLQSAAEPAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYKL
GIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSEAPVFSSIRVNVGTRLPAHATTHGHV
LMGDLSLDELRALYPEGTLPRMTNATPDTVDALYTMIREDALRGYGISNSSFERGISVVTAPVRNDTQKIVACITVTVPR
PEIDATLIADGLIDKVRRAAAELSRRLNYRSDDEHTFLKALGLR
MSEPLQSAAEPAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYKL
GIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSEAPVFSSIRVNVGTRLPAHATTHGHV
LMGDLSLDELRALYPEGTLPRMTNATPDTVDALYTMIREDALRGYGISNSSFERGISVVTAPVRNDTQKIVACITVTVPR
PEIDATLIADGLIDKVRRAAAELSRRLNYRSDDEHTFLKALGLR
Download Length: 855 bp
>AT231717 NZ_CP126945:c68179-67949 [Escherichia coli O1:K1:H7]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|