Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 769070..769725 Replicon chromosome
Accession NZ_CP090722
Organism Burkholderia multivorans strain 2014Y70522077

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Z19_RS19190 Protein ID WP_006409935.1
Coordinates 769306..769725 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L0Z19_RS19185 Protein ID WP_249462451.1
Coordinates 769070..769309 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z19_RS19160 (L0Z19_19160) 764131..764274 - 144 WP_006409932.1 hypothetical protein -
L0Z19_RS19165 (L0Z19_19165) 764863..765066 + 204 WP_006403067.1 hypothetical protein -
L0Z19_RS19170 (L0Z19_19170) 765093..765764 - 672 Protein_630 Fe2+-dependent dioxygenase -
L0Z19_RS19175 (L0Z19_19175) 765761..766516 - 756 WP_006403069.1 tetratricopeptide repeat protein -
L0Z19_RS19180 (L0Z19_19180) 766520..768766 - 2247 WP_006403070.1 TonB-dependent siderophore receptor -
L0Z19_RS19185 (L0Z19_19185) 769070..769309 + 240 WP_249462451.1 Arc family DNA-binding protein Antitoxin
L0Z19_RS19190 (L0Z19_19190) 769306..769725 + 420 WP_006409935.1 type II toxin-antitoxin system VapC family toxin Toxin
L0Z19_RS19195 (L0Z19_19195) 769859..771154 - 1296 WP_249462452.1 aspartate carbamoyltransferase -
L0Z19_RS19200 (L0Z19_19200) 771387..771521 + 135 WP_006409923.1 entericidin A/B family lipoprotein -
L0Z19_RS19205 (L0Z19_19205) 771615..772190 - 576 WP_053298362.1 hypothetical protein -
L0Z19_RS19210 (L0Z19_19210) 772386..773336 - 951 WP_217057526.1 DMT family transporter -
L0Z19_RS19215 (L0Z19_19215) 773582..774376 - 795 WP_105777245.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15146.38 Da        Isoelectric Point: 5.2157

>T231716 WP_006409935.1 NZ_CP090722:769306-769725 [Burkholderia multivorans]
MILVDTNVIFEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFGVAALPEGRRRDWLEQSIEHRVVPVFRGRILPFDD
AAGKAYARIRAHARAVGNAIAPADGYIAATAEANGLIVATRDVAPFEAAGLRVIDPWAS

Download         Length: 420 bp

>T231716 NZ_CP126944:c4933220-4932909 [Escherichia coli O1:K1:H7]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8788.06 Da        Isoelectric Point: 5.7066

>AT231716 WP_249462451.1 NZ_CP090722:769070-769309 [Burkholderia multivorans]
MPVITVRNLPDEVHRALRVRAALHGRSIEAEVRDILEQAVLSEGRVKLGTLLAEIGREAGGVDLDIQRDKTRTDPMSFE

Download         Length: 240 bp

>AT231716 NZ_CP126944:c4932908-4932618 [Escherichia coli O1:K1:H7]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References