Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 608117..609387 Replicon chromosome
Accession NZ_CP090722
Organism Burkholderia multivorans strain 2014Y70522077

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Z19_RS18520 Protein ID WP_105774903.1
Coordinates 608117..608695 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L0Z19_RS18525 Protein ID WP_217085942.1
Coordinates 608830..609387 (-) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z19_RS18500 (L0Z19_18500) 603405..604196 + 792 WP_065496148.1 enoyl-CoA hydratase -
L0Z19_RS18505 (L0Z19_18505) 604193..605332 + 1140 WP_006410588.1 enoyl-CoA hydratase/isomerase family protein -
L0Z19_RS18510 (L0Z19_18510) 605379..606299 - 921 WP_065496151.1 LysR family transcriptional regulator -
L0Z19_RS18515 (L0Z19_18515) 606478..608016 + 1539 WP_249462417.1 MFS transporter -
L0Z19_RS18520 (L0Z19_18520) 608117..608695 - 579 WP_105774903.1 HD domain-containing protein Toxin
L0Z19_RS18525 (L0Z19_18525) 608830..609387 - 558 WP_217085942.1 helix-turn-helix transcriptional regulator Antitoxin
L0Z19_RS18530 (L0Z19_18530) 609900..611303 + 1404 WP_088929364.1 hypothetical protein -
L0Z19_RS18535 (L0Z19_18535) 611314..611934 - 621 WP_006410617.1 isochorismatase family cysteine hydrolase -
L0Z19_RS18540 (L0Z19_18540) 612526..612969 - 444 WP_223852633.1 antibiotic biosynthesis monooxygenase -
L0Z19_RS18545 (L0Z19_18545) 613069..614094 - 1026 WP_006406131.1 aldo/keto reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-173)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21461.19 Da        Isoelectric Point: 5.2986

>T231715 WP_105774903.1 NZ_CP090722:c608695-608117 [Burkholderia multivorans]
MNPDTIRARLDFLREAERLKDVLRSGRTSSGRRESTAEHSWRLCLMALVFADALHGIDTLKLLKLCVVHDLGEALHGDIP
APEQAAHPDKNMHERDDLLTLTAALDPVLRNELVALWDEYDVAASPEARAAKALDKLETILQHTQGANPPDFDYAFNLDY
GRRYTDAAPLFSAIRAIVDADTQRRIDAQAHT

Download         Length: 579 bp

>T231715 NZ_CP126944:c4627107-4626934 [Escherichia coli O1:K1:H7]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTTCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20304.26 Da        Isoelectric Point: 8.1964

>AT231715 WP_217085942.1 NZ_CP090722:c609387-608830 [Burkholderia multivorans]
MPDSPLHTPPLGPQLKRWRLLHRVKQSHAAELFGVAQSTISRWEAGVQQMSPDERATAERLLAAHLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPSRAAEFSQPLSMLLGTSLWRYATEEIVRMETALDTLGWHDCAGPPSVEFDTGTNASRVVP
IHRSRCRWTRIMLSGGAAARLVETL

Download         Length: 558 bp

>AT231715 NZ_CP126944:c4627431-4627135 [Escherichia coli O1:K1:H7]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References