Detailed information of TA system TA231714

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/Tad-HTH_37
• Location: 2457273..2457973
• Replicon: chromosome
• Accession: NZ_CP090721
• Organism: Burkholderia multivorans strain 2014Y70522077

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: L0Z19_RS11745
• Protein ID: WP_105801035.1
• Coordinates: 2457273..2457650 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: B9BQB8
• Locus tag: L0Z19_RS11750
• Protein ID: WP_006405635.1
• Coordinates: 2457650..2457973 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z19_RS11715 (L0Z19_11715)	2452817..2453263	+	447	WP_006405630.1	VOC family protein	-
L0Z19_RS11720 (L0Z19_11720)	2453367..2454917	-	1551	WP_006398698.1	sodium:solute symporter family protein	-
L0Z19_RS11725 (L0Z19_11725)	2454914..2455147	-	234	WP_006398697.1	DUF3311 domain-containing protein	-
L0Z19_RS11730 (L0Z19_11730)	2455344..2456261	-	918	WP_088930384.1	spermidine synthase	-
L0Z19_RS11735 (L0Z19_11735)	2456489..2456743	+	255	WP_059940739.1	hypothetical protein	-
L0Z19_RS11740 (L0Z19_11740)	2456920..2457288	-	369	WP_249463891.1	hypothetical protein	-
L0Z19_RS11745 (L0Z19_11745)	2457273..2457650	+	378	WP_105801035.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L0Z19_RS11750 (L0Z19_11750)	2457650..2457973	+	324	WP_006405635.1	helix-turn-helix transcriptional regulator	Antitoxin
L0Z19_RS11755 (L0Z19_11755)	2457996..2458487	-	492	WP_249463437.1	DNA-deoxyinosine glycosylase	-
L0Z19_RS11760 (L0Z19_11760)	2458484..2459098	-	615	WP_249463432.1	chorismate lyase	-
L0Z19_RS11765 (L0Z19_11765)	2459107..2461005	-	1899	WP_059875776.1	molecular chaperone HtpG	-
L0Z19_RS11770 (L0Z19_11770)	2461164..2462624	-	1461	WP_006405639.1	PLP-dependent aminotransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (23-114)

Antitoxin

• Cro/C1-type helix-turn-helix domain (30-85)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13598.65 Da
• Isoelectric Point: 9.7722

>T231714 WP_105801035.1 NZ_CP090721:2457273-2457650 [Burkholderia multivorans]
MGINSSMVPYTKPLYWLGSARKHLKAMPEAVQDTFGYALYLAQTGGKHDQAKPLRGFGSAGVLEVVESEDSGTYRAVYTV
KLGGAVYVLHCFQKKSCRGIATPKPDIELVRARLRAAEAHANGEK

Nucleotide

• Length: 378 bp

>T231714 NZ_CP126944:4615804-4616181 [Escherichia coli O1:K1:H7]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGATCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAATATTATCCTGGGTAAGCACCCGGAGGTGAAACAATGA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11828.69 Da
• Isoelectric Point: 8.0686

>AT231714 WP_006405635.1 NZ_CP090721:2457650-2457973 [Burkholderia multivorans]
MIEIERGSGNVYADLGTPDAEEMRVKAQLAAKIAEIIKTRKWTQQHAARLLGMTQPKLSNMLRGQFRGVSEAKMLDCLAK
LGRDVQIVVGPDRHSETEGHIEVVFAA

Nucleotide

• Length: 324 bp

>AT231714 NZ_CP126944:4615347-4615715 [Escherichia coli O1:K1:H7]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGTACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Structures

Antitoxin

• AlphaFold DB: B9BQB8