Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 125321..125967 Replicon plasmid p1_2014Y70532416II
Accession NZ_CP090720
Organism Burkholderia multivorans strain 2014Y70532416II

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Y81_RS30480 Protein ID WP_012211060.1
Coordinates 125321..125728 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L0Y81_RS30485 Protein ID WP_009692911.1
Coordinates 125725..125967 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y81_RS30445 (L0Y81_30445) 121605..122336 - 732 WP_009692920.1 hypothetical protein -
L0Y81_RS30450 (L0Y81_30450) 122333..122641 - 309 WP_009692919.1 hypothetical protein -
L0Y81_RS30455 (L0Y81_30455) 122652..122837 - 186 WP_009692918.1 hypothetical protein -
L0Y81_RS30460 (L0Y81_30460) 122949..123869 - 921 WP_009692917.1 serine protease -
L0Y81_RS30465 (L0Y81_30465) 123862..124020 - 159 WP_009692916.1 hypothetical protein -
L0Y81_RS30470 (L0Y81_30470) 124017..124625 - 609 WP_012211062.1 hypothetical protein -
L0Y81_RS30475 (L0Y81_30475) 124657..124977 - 321 WP_012211061.1 hypothetical protein -
L0Y81_RS30480 (L0Y81_30480) 125321..125728 - 408 WP_012211060.1 type II toxin-antitoxin system VapC family toxin Toxin
L0Y81_RS30485 (L0Y81_30485) 125725..125967 - 243 WP_009692911.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
L0Y81_RS30490 (L0Y81_30490) 126069..127037 - 969 WP_231856867.1 non-homologous end-joining DNA ligase -
L0Y81_RS30495 (L0Y81_30495) 127594..128265 + 672 WP_012211058.1 AAA family ATPase -
L0Y81_RS30500 (L0Y81_30500) 128265..129230 + 966 WP_012211057.1 ParB/RepB/Spo0J family partition protein -
L0Y81_RS30505 (L0Y81_30505) 129975..130832 + 858 WP_012211056.1 plasmid replication initiator TrfA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..156152 156152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(12-49)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14613.77 Da        Isoelectric Point: 5.1402

>T231712 WP_012211060.1 NZ_CP090720:c125728-125321 [Burkholderia multivorans]
MSLYLLDTNILSNVIRDPRGACASRIGETRPEQVCTSIVVAAELRYGVCKRGSSALAQRVEQLLASLTVLPLQSDADQCY
GRLRADLERQGQLIGANDMLIAAHAMAVDAVLVTDNTAEFTRVTGLAVENWLRPA

Download         Length: 408 bp

>T231712 NZ_CP126944:4300837-4301178 [Escherichia coli O1:K1:H7]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGGTTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9309.54 Da        Isoelectric Point: 4.8615

>AT231712 WP_009692911.1 NZ_CP090720:c125967-125725 [Burkholderia multivorans]
MPTHDTRHARLFRNGRSQAVRIPREFELPVSEVTIHREGRRLIIEPVEAPSLRELFAQWAPLDETFPDIENLPAEPVDIE

Download         Length: 243 bp

>AT231712 NZ_CP126944:c4300842-4300766 [Escherichia coli O1:K1:H7]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCAGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References