Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 1992276..1992896 Replicon chromosome
Accession NZ_CP090717
Organism Burkholderia multivorans strain 2014Y70532416II

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3KJN2
Locus tag L0Y81_RS08570 Protein ID WP_012217495.1
Coordinates 1992276..1992593 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID B9B269
Locus tag L0Y81_RS08575 Protein ID WP_006398012.1
Coordinates 1992597..1992896 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y81_RS08560 (L0Y81_08560) 1988811..1990244 - 1434 WP_105771374.1 aldehyde dehydrogenase family protein -
L0Y81_RS08565 (L0Y81_08565) 1990273..1991913 - 1641 WP_006398015.1 acetolactate synthase large subunit -
L0Y81_RS08570 (L0Y81_08570) 1992276..1992593 + 318 WP_012217495.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0Y81_RS08575 (L0Y81_08575) 1992597..1992896 + 300 WP_006398012.1 putative addiction module antidote protein Antitoxin
L0Y81_RS08580 (L0Y81_08580) 1992931..1994217 - 1287 WP_039225729.1 DUF445 domain-containing protein -
L0Y81_RS08585 (L0Y81_08585) 1994331..1995551 - 1221 WP_105835569.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
L0Y81_RS08590 (L0Y81_08590) 1995541..1995867 - 327 WP_006404219.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
L0Y81_RS08595 (L0Y81_08595) 1995885..1996373 - 489 WP_006398008.1 anthranilate 1,2-dioxygenase small subunit AndAd -
L0Y81_RS08600 (L0Y81_08600) 1996388..1997659 - 1272 WP_105835568.1 anthranilate 1,2-dioxygenase large subunit AndAc -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-102)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.94 Da        Isoelectric Point: 10.2349

>T231710 WP_012217495.1 NZ_CP090717:1992276-1992593 [Burkholderia multivorans]
MPYLAPTFSIRTTAVFDAWFAGLQDRTAKRRIQARIDRLSMGNLGNWKSVGSPVYEMRIDHGPGYRVYFVRRRTIWVVLL
CGGDKSTQRDDIRAAHAMLEHLDLE

Download         Length: 318 bp

>T231710 NZ_CP126944:c3906282-3905884 [Escherichia coli O1:K1:H7]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGAAGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGTGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGCAGCGCATTTGGTATATTGTCAGGGCGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10605.00 Da        Isoelectric Point: 6.6381

>AT231710 WP_006398012.1 NZ_CP090717:1992597-1992896 [Burkholderia multivorans]
MSKISTRPWDSAEHLKTDDDMAEYFEACLQEGGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp

>AT231710 NZ_CP126944:c3906578-3906285 [Escherichia coli O1:K1:H7]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
TGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTTGAAGCATTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCGAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KJN2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3KTI5

References