Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relE-PumB/upstrm_HI1419-dnstrm_HI1420 |
Location | 1992276..1992896 | Replicon | chromosome |
Accession | NZ_CP090717 | ||
Organism | Burkholderia multivorans strain 2014Y70532416II |
Toxin (Protein)
Gene name | relE | Uniprot ID | A0A0H3KJN2 |
Locus tag | L0Y81_RS08570 | Protein ID | WP_012217495.1 |
Coordinates | 1992276..1992593 (+) | Length | 106 a.a. |
Antitoxin (Protein)
Gene name | PumB | Uniprot ID | B9B269 |
Locus tag | L0Y81_RS08575 | Protein ID | WP_006398012.1 |
Coordinates | 1992597..1992896 (+) | Length | 100 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
L0Y81_RS08560 (L0Y81_08560) | 1988811..1990244 | - | 1434 | WP_105771374.1 | aldehyde dehydrogenase family protein | - |
L0Y81_RS08565 (L0Y81_08565) | 1990273..1991913 | - | 1641 | WP_006398015.1 | acetolactate synthase large subunit | - |
L0Y81_RS08570 (L0Y81_08570) | 1992276..1992593 | + | 318 | WP_012217495.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
L0Y81_RS08575 (L0Y81_08575) | 1992597..1992896 | + | 300 | WP_006398012.1 | putative addiction module antidote protein | Antitoxin |
L0Y81_RS08580 (L0Y81_08580) | 1992931..1994217 | - | 1287 | WP_039225729.1 | DUF445 domain-containing protein | - |
L0Y81_RS08585 (L0Y81_08585) | 1994331..1995551 | - | 1221 | WP_105835569.1 | anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase | - |
L0Y81_RS08590 (L0Y81_08590) | 1995541..1995867 | - | 327 | WP_006404219.1 | anthranilate 1,2-dioxygenase ferredoxin subunit AndAb | - |
L0Y81_RS08595 (L0Y81_08595) | 1995885..1996373 | - | 489 | WP_006398008.1 | anthranilate 1,2-dioxygenase small subunit AndAd | - |
L0Y81_RS08600 (L0Y81_08600) | 1996388..1997659 | - | 1272 | WP_105835568.1 | anthranilate 1,2-dioxygenase large subunit AndAc | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12110.94 Da Isoelectric Point: 10.2349
>T231710 WP_012217495.1 NZ_CP090717:1992276-1992593 [Burkholderia multivorans]
MPYLAPTFSIRTTAVFDAWFAGLQDRTAKRRIQARIDRLSMGNLGNWKSVGSPVYEMRIDHGPGYRVYFVRRRTIWVVLL
CGGDKSTQRDDIRAAHAMLEHLDLE
MPYLAPTFSIRTTAVFDAWFAGLQDRTAKRRIQARIDRLSMGNLGNWKSVGSPVYEMRIDHGPGYRVYFVRRRTIWVVLL
CGGDKSTQRDDIRAAHAMLEHLDLE
Download Length: 318 bp
>T231710 NZ_CP126944:c3906282-3905884 [Escherichia coli O1:K1:H7]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGAAGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGTGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGCAGCGCATTTGGTATATTGTCAGGGCGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGAAGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGTGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGCAGCGCATTTGGTATATTGTCAGGGCGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
Antitoxin
Download Length: 100 a.a. Molecular weight: 10605.00 Da Isoelectric Point: 6.6381
>AT231710 WP_006398012.1 NZ_CP090717:1992597-1992896 [Burkholderia multivorans]
MSKISTRPWDSAEHLKTDDDMAEYFEACLQEGGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA
MSKISTRPWDSAEHLKTDDDMAEYFEACLQEGGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA
Download Length: 300 bp
>AT231710 NZ_CP126944:c3906578-3906285 [Escherichia coli O1:K1:H7]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
TGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTTGAAGCATTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCGAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
TGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTTGAAGCATTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCGAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3KJN2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3KTI5 |