Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 1370867..1371906 | Replicon | chromosome |
| Accession | NZ_CP090717 | ||
| Organism | Burkholderia multivorans strain 2014Y70532416II | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | A0A1W0YRD2 |
| Locus tag | L0Y81_RS05865 | Protein ID | WP_060096181.1 |
| Coordinates | 1370867..1371442 (-) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | - |
| Locus tag | L0Y81_RS05870 | Protein ID | WP_054316743.1 |
| Coordinates | 1371439..1371906 (-) | Length | 156 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L0Y81_RS05835 (L0Y81_05835) | 1366257..1367339 | + | 1083 | WP_006415045.1 | porin | - |
| L0Y81_RS05840 (L0Y81_05840) | 1367475..1368125 | - | 651 | WP_244130927.1 | hypothetical protein | - |
| L0Y81_RS05845 (L0Y81_05845) | 1368253..1368363 | + | 111 | Protein_1161 | porin | - |
| L0Y81_RS05850 (L0Y81_05850) | 1368422..1369387 | - | 966 | WP_105836659.1 | zinc-binding alcohol dehydrogenase family protein | - |
| L0Y81_RS05855 (L0Y81_05855) | 1369466..1369717 | - | 252 | WP_039218251.1 | hypothetical protein | - |
| L0Y81_RS05860 (L0Y81_05860) | 1369813..1370622 | + | 810 | WP_105836660.1 | helix-turn-helix transcriptional regulator | - |
| L0Y81_RS05865 (L0Y81_05865) | 1370867..1371442 | - | 576 | WP_060096181.1 | PIN domain-containing protein | Toxin |
| L0Y81_RS05870 (L0Y81_05870) | 1371439..1371906 | - | 468 | WP_054316743.1 | helix-turn-helix domain-containing protein | Antitoxin |
| L0Y81_RS05875 (L0Y81_05875) | 1372022..1372828 | - | 807 | WP_105836661.1 | 4-hydroxy-2-oxoheptanedioate aldolase | - |
| L0Y81_RS05880 (L0Y81_05880) | 1372836..1373639 | - | 804 | WP_105842135.1 | 2-oxo-hepta-3-ene-1,7-dioic acid hydratase | - |
| L0Y81_RS05885 (L0Y81_05885) | 1373654..1374046 | - | 393 | WP_006403681.1 | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | - |
| L0Y81_RS05890 (L0Y81_05890) | 1374082..1374930 | - | 849 | WP_012217098.1 | 3,4-dihydroxyphenylacetate 2,3-dioxygenase | - |
| L0Y81_RS05895 (L0Y81_05895) | 1374973..1376436 | - | 1464 | WP_105836663.1 | 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21554.67 Da Isoelectric Point: 5.0551
>T231709 WP_060096181.1 NZ_CP090717:c1371442-1370867 [Burkholderia multivorans]
MTHSPFTAIYDACVLYPAPLRDFLMRLALSGCFRARWSAHITDEWKRNLLDNRPDLTAEQLDRTSSLMDRAIPDAVVTGY
ESLIAGLVLPDADDRHVLAAAIRCNASVIVTFNRKDFPEEALLPYGIEAQHPDEFVDNLFDLEPAVVVAAARRQREALKQ
PPLTADRYLEILRRQGMVQTCQSLDAYRALL
MTHSPFTAIYDACVLYPAPLRDFLMRLALSGCFRARWSAHITDEWKRNLLDNRPDLTAEQLDRTSSLMDRAIPDAVVTGY
ESLIAGLVLPDADDRHVLAAAIRCNASVIVTFNRKDFPEEALLPYGIEAQHPDEFVDNLFDLEPAVVVAAARRQREALKQ
PPLTADRYLEILRRQGMVQTCQSLDAYRALL
Download Length: 576 bp
>T231709 NZ_CP126944:3693903-3694121 [Escherichia coli O1:K1:H7]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGTCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGTCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
Antitoxin
Download Length: 156 a.a. Molecular weight: 17581.02 Da Isoelectric Point: 6.1443
>AT231709 WP_054316743.1 NZ_CP090717:c1371906-1371439 [Burkholderia multivorans]
MHHATTPDMILPVEREMQAAVEGQRMLAAYLATRTDTQRIQIFDDENRAHQVELPTSALRLLVDILAELADGNAVKVVPV
HAELTTQEAADLLNVSRPHLIKLLESNALPYHRTGKHRRVRFSDLMRYKAERDQESADAMEELGKQAQALRMGYE
MHHATTPDMILPVEREMQAAVEGQRMLAAYLATRTDTQRIQIFDDENRAHQVELPTSALRLLVDILAELADGNAVKVVPV
HAELTTQEAADLLNVSRPHLIKLLESNALPYHRTGKHRRVRFSDLMRYKAERDQESADAMEELGKQAQALRMGYE
Download Length: 468 bp
>AT231709 NZ_CP126944:3693503-3693877 [Escherichia coli O1:K1:H7]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|