Detailed information of TA system TA231708

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 1232525..1233059
• Replicon: chromosome
• Accession: NZ_CP090717
• Organism: Burkholderia multivorans strain 2014Y70532416II

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A1W0YQN7
• Locus tag: L0Y81_RS05225
• Protein ID: WP_035954873.1
• Coordinates: 1232525..1232824 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: L0Y81_RS05230
• Protein ID: WP_105836542.1
• Coordinates: 1232814..1233059 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Y81_RS05210 (L0Y81_05210)	1228875..1230182	+	1308	WP_039218025.1	shikimate transporter	-
L0Y81_RS05215 (L0Y81_05215)	1230217..1230834	-	618	WP_006397056.1	HNH endonuclease	-
L0Y81_RS05220 (L0Y81_05220)	1231116..1232417	+	1302	WP_006413706.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
L0Y81_RS05225 (L0Y81_05225)	1232525..1232824	-	300	WP_035954873.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L0Y81_RS05230 (L0Y81_05230)	1232814..1233059	-	246	WP_105836542.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
L0Y81_RS05235 (L0Y81_05235)	1233199..1233969	+	771	WP_249458891.1	IclR family transcriptional regulator C-terminal domain-containing protein	-
L0Y81_RS05240 (L0Y81_05240)	1234032..1236332	-	2301	WP_175848076.1	ATP-dependent DNA helicase	-
L0Y81_RS05245 (L0Y81_05245)	1236329..1238032	-	1704	WP_105836543.1	VRR-NUC domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-94)

Antitoxin

• Antitoxin ParD (1-80)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11570.09 Da
• Isoelectric Point: 7.3154

>T231708 WP_035954873.1 NZ_CP090717:c1232824-1232525 [Burkholderia multivorans]
MPVKARTVRLTPLAEADLEAIWAYTYERWSLDQAERYIGELSAAFERLARRESVGWPSRAGGNYSRYLVGSHVVFYRETT
ETLDVIRVLHQRMDVDRHL

Nucleotide

• Length: 300 bp

>T231708 NZ_CP126944:c3664780-3664478 [Escherichia coli O1:K1:H7]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATTGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8648.71 Da
• Isoelectric Point: 6.4592

>AT231708 WP_105836542.1 NZ_CP090717:c1233059-1232814 [Burkholderia multivorans]
MARNTSISLGDHLTEFVDMQVASGRYGSASDVVRAGLRLLETQETELRALQEALKAGDASGTPAPFDSQAFLARMRAKHA
G

Nucleotide

• Length: 246 bp

>AT231708 NZ_CP126944:c3664442-3664101 [Escherichia coli O1:K1:H7]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Structures

Toxin

• AlphaFold DB: A0A1W0YQN7