Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
| Location | 921395..923142 | Replicon | chromosome |
| Accession | NZ_CP090717 | ||
| Organism | Burkholderia multivorans strain 2014Y70532416II | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | - |
| Locus tag | L0Y81_RS03975 | Protein ID | WP_105836409.1 |
| Coordinates | 921395..922291 (+) | Length | 299 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | B9AZJ2 |
| Locus tag | L0Y81_RS03980 | Protein ID | WP_006396780.1 |
| Coordinates | 922288..923142 (+) | Length | 285 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L0Y81_RS03945 (L0Y81_03945) | 916795..917874 | - | 1080 | WP_039217461.1 | porin | - |
| L0Y81_RS03950 (L0Y81_03950) | 918310..918627 | + | 318 | WP_006396774.1 | non-heme iron oxygenase ferredoxin subunit | - |
| L0Y81_RS03955 (L0Y81_03955) | 918629..918940 | + | 312 | WP_006396775.1 | hypothetical protein | - |
| L0Y81_RS03960 (L0Y81_03960) | 918988..920058 | + | 1071 | WP_175848021.1 | aromatic ring-hydroxylating dioxygenase subunit alpha | - |
| L0Y81_RS03965 (L0Y81_03965) | 920051..920821 | + | 771 | WP_006413827.1 | SDR family oxidoreductase | - |
| L0Y81_RS03970 (L0Y81_03970) | 920849..921376 | + | 528 | WP_006396778.1 | cupin domain-containing protein | - |
| L0Y81_RS03975 (L0Y81_03975) | 921395..922291 | + | 897 | WP_105836409.1 | alpha/beta fold hydrolase | Toxin |
| L0Y81_RS03980 (L0Y81_03980) | 922288..923142 | + | 855 | WP_006396780.1 | IclR family transcriptional regulator | Antitoxin |
| L0Y81_RS03985 (L0Y81_03985) | 923139..923936 | + | 798 | WP_006396781.1 | SDR family oxidoreductase | - |
| L0Y81_RS03990 (L0Y81_03990) | 923929..925596 | + | 1668 | WP_249458835.1 | thiamine pyrophosphate-binding protein | - |
| L0Y81_RS03995 (L0Y81_03995) | 925589..926419 | + | 831 | WP_105836412.1 | aspartate dehydrogenase | - |
| L0Y81_RS04000 (L0Y81_04000) | 926477..927967 | + | 1491 | WP_043278809.1 | aldehyde dehydrogenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 299 a.a. Molecular weight: 30543.77 Da Isoelectric Point: 8.0534
>T231706 WP_105836409.1 NZ_CP090717:921395-922291 [Burkholderia multivorans]
MSVVDKRERDRTAAFGTLLERFPEQRCAAGAAGTIGYREAGAQHAGAALAVVLLHGIGSGAASWVRQLDALGASRRVLAW
DAPGYGASTPVHGASPSAVDYAASLDAWLDALGIARCVLVGHSLGAIVAGGMVRVKPERIAGLLLISPAGGYGSAPAETR
ASRRDARLAMLAELGPAGLAAQRSGNMLSGFATEDARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAGVGLQVIPQAGHAGYVEAPDVYSALIDTFCRQCDIERRAA
MSVVDKRERDRTAAFGTLLERFPEQRCAAGAAGTIGYREAGAQHAGAALAVVLLHGIGSGAASWVRQLDALGASRRVLAW
DAPGYGASTPVHGASPSAVDYAASLDAWLDALGIARCVLVGHSLGAIVAGGMVRVKPERIAGLLLISPAGGYGSAPAETR
ASRRDARLAMLAELGPAGLAAQRSGNMLSGFATEDARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAGVGLQVIPQAGHAGYVEAPDVYSALIDTFCRQCDIERRAA
Download Length: 897 bp
>T231706 NZ_CP126944:2620416-2620694 [Escherichia coli O1:K1:H7]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA
Antitoxin
Download Length: 285 a.a. Molecular weight: 31176.75 Da Isoelectric Point: 6.6558
>AT231706 WP_006396780.1 NZ_CP090717:922288-923142 [Burkholderia multivorans]
MSEPLQSAAEPAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYKL
GIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSEAPVFSSIRVNVGTRLPAHATTHGHV
LMGDLSLDELRALYPEGTLPRMTNATPDTVDALYTMIREDALRGYGISNSSFERGISVVTAPVRNDTQKIVACITVTVPR
PEIDATLIADGLIDKVRRAAAELSRRLNYRSDDEHTFLKALGLR
MSEPLQSAAEPAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYKL
GIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSEAPVFSSIRVNVGTRLPAHATTHGHV
LMGDLSLDELRALYPEGTLPRMTNATPDTVDALYTMIREDALRGYGISNSSFERGISVVTAPVRNDTQKIVACITVTVPR
PEIDATLIADGLIDKVRRAAAELSRRLNYRSDDEHTFLKALGLR
Download Length: 855 bp
>AT231706 NZ_CP126944:2620694-2620978 [Escherichia coli O1:K1:H7]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCGGAA
AAAACGGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCGGAA
AAAACGGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|