Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 787065..787756 Replicon chromosome
Accession NZ_CP090717
Organism Burkholderia multivorans strain 2014Y70532416II

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Y81_RS03350 Protein ID WP_065496260.1
Coordinates 787301..787756 (+) Length 152 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L0Y81_RS03345 Protein ID WP_065496259.1
Coordinates 787065..787304 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y81_RS03320 (L0Y81_03320) 782126..782269 - 144 WP_006409932.1 hypothetical protein -
L0Y81_RS03325 (L0Y81_03325) 782858..783061 + 204 WP_006396646.1 hypothetical protein -
L0Y81_RS03330 (L0Y81_03330) 783075..783758 - 684 WP_105835359.1 Fe2+-dependent dioxygenase -
L0Y81_RS03335 (L0Y81_03335) 783755..784510 - 756 WP_175848494.1 tetratricopeptide repeat protein -
L0Y81_RS03340 (L0Y81_03340) 784514..786760 - 2247 WP_012216643.1 TonB-dependent siderophore receptor -
L0Y81_RS03345 (L0Y81_03345) 787065..787304 + 240 WP_065496259.1 Arc family DNA-binding protein Antitoxin
L0Y81_RS03350 (L0Y81_03350) 787301..787756 + 456 WP_065496260.1 type II toxin-antitoxin system VapC family toxin Toxin
L0Y81_RS03355 (L0Y81_03355) 787853..789148 - 1296 WP_035487510.1 aspartate carbamoyltransferase -
L0Y81_RS03360 (L0Y81_03360) 789381..789515 + 135 WP_006396654.1 entericidin A/B family lipoprotein -
L0Y81_RS03365 (L0Y81_03365) 789608..790177 - 570 WP_105835361.1 permease -
L0Y81_RS03370 (L0Y81_03370) 790373..791323 - 951 WP_175848493.1 DMT family transporter -
L0Y81_RS03375 (L0Y81_03375) 791915..792709 - 795 WP_105835364.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-46)


Sequences

Toxin        


Download         Length: 152 a.a.        Molecular weight: 16209.56 Da        Isoelectric Point: 7.2060

>T231705 WP_065496260.1 NZ_CP090717:787301-787756 [Burkholderia multivorans]
MILVDTNVISEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFGVAALPEGRRRDWLAQSIEHRVVPVFRGRILPFDD
AASKAYARIRAHARAGGNAIAPADGYIAATAEANGLIVATRDVAPFEAAGLRVIDPWASQGAPVRQGIASK

Download         Length: 456 bp

>T231705 NZ_CP126944:2583660-2584982 [Escherichia coli O1:K1:H7]
ATGCCTAAACTAGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCTGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGAGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATCCCCGAAGA
TGAAACCGTAATGTGTCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGTTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACTGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAGGGAATAACGCCAACGACGCACATTATCAAATTGCCGATTGGCGAAAT
CAGACAGCCCAATGCGACGCTCGATCTTAGCCAAAGCGTTGATAATGAGTATTACTGTTTGCTGCTGGCGAAAGAACTCG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCAAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGCCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCCGGTATCGCGCAAATTATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTCTTCCAGTGGTTGATTGGCGCAACAGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGGCTCACACCATTTTATGACATCATTTCGGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACGGTCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8750.96 Da        Isoelectric Point: 5.1133

>AT231705 WP_065496259.1 NZ_CP090717:787065-787304 [Burkholderia multivorans]
MPVITVRNLPDEVHRALRVRAALHGRSTEAEVRDILEQAVLSEGRVKLGTLLAEIGREAGGVDFDIQRDKTPTDPMSFE

Download         Length: 240 bp

>AT231705 NZ_CP126944:2583394-2583660 [Escherichia coli O1:K1:H7]
ATGATGAGCTTTCAGAAGATCTATAGCCCAATGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAACGGCTGGAC
GCAGAGCGAGTTGGCGAAAAAAATCGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAATCCTAACAATACCTCGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCAAAAAATGCCTCGCCAGAAGCA
ACAGAACAGCAAGATCTGGAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References