Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 625520..626819 Replicon chromosome
Accession NZ_CP090717
Organism Burkholderia multivorans strain 2014Y70532416II

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Y81_RS02695 Protein ID WP_105835289.1
Coordinates 625520..626131 (-) Length 204 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L0Y81_RS02700 Protein ID WP_039216965.1
Coordinates 626262..626819 (-) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y81_RS02675 (L0Y81_02675) 620849..621640 + 792 WP_035955458.1 enoyl-CoA hydratase -
L0Y81_RS02680 (L0Y81_02680) 621637..622776 + 1140 WP_035955456.1 enoyl-CoA hydratase/isomerase family protein -
L0Y81_RS02685 (L0Y81_02685) 622823..623743 - 921 WP_006406123.1 LysR family transcriptional regulator -
L0Y81_RS02690 (L0Y81_02690) 623922..625460 + 1539 WP_105810115.1 MFS transporter -
L0Y81_RS02695 (L0Y81_02695) 625520..626131 - 612 WP_105835289.1 HD domain-containing protein Toxin
L0Y81_RS02700 (L0Y81_02700) 626262..626819 - 558 WP_039216965.1 helix-turn-helix transcriptional regulator Antitoxin
L0Y81_RS02705 (L0Y81_02705) 627329..628732 + 1404 WP_006396486.1 hypothetical protein -
L0Y81_RS02710 (L0Y81_02710) 629074..629805 + 732 WP_012216547.1 ribonuclease T2 -
L0Y81_RS02715 (L0Y81_02715) 629867..630499 - 633 WP_105835291.1 isochorismatase family cysteine hydrolase -
L0Y81_RS02720 (L0Y81_02720) 631056..631652 + 597 WP_244131027.1 Crp/Fnr family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(6-189)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 204 a.a.        Molecular weight: 22627.45 Da        Isoelectric Point: 5.5913

>T231704 WP_105835289.1 NZ_CP090717:c626131-625520 [Burkholderia multivorans]
MNPDTIRARLDFLREAERLKDVLRSGRTSSGRRESTAEHSWRLCLMVLVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
ATEQAAHPEKNMHERDDLLTLTAALDPVLRDELVALWDEYDAAASPEARAAKALDKLETILQHTQGANPPDFDYAFNLGY
GRRYTDAAPLFSAIRAIVDADTQRRIDAQAQTSSQTQTRTHRA

Download         Length: 612 bp

>T231704 NZ_CP126944:2297765-2297867 [Escherichia coli O1:K1:H7]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20377.36 Da        Isoelectric Point: 8.5509

>AT231704 WP_039216965.1 NZ_CP090717:c626819-626262 [Burkholderia multivorans]
MPDSPLHTPPLGPQLRRWRLLHRVKQSHAAALFGVAQSTISRWEAGVQQMSPDERATAERLLAARLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPSRAAEFSQPLPMLLGTSLWRYATEEIVRMETALDTLGWHDCAGPPSVEFDTGTNASRVVP
IHRSRCRWTRIMLSDGSAARLVETL

Download         Length: 558 bp

>AT231704 NZ_CP126944:c2297905-2297637 [Escherichia coli O1:K1:H7]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References