Detailed information of TA system TA231703

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpSB/PRK09812-ChpS
• Location: 296729..297324
• Replicon: chromosome
• Accession: NZ_CP090717
• Organism: Burkholderia multivorans strain 2014Y70532416II

Toxin (Protein)

• Gene name: chpB
• Uniprot ID: -
• Locus tag: L0Y81_RS01255
• Protein ID: WP_105834886.1
• Coordinates: 296729..297079 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: -
• Locus tag: L0Y81_RS01260
• Protein ID: WP_105834901.1
• Coordinates: 297073..297324 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Y81_RS01245 (L0Y81_01245)	291819..295004	+	3186	WP_249458849.1	multidrug efflux RND transporter permease subunit CeoB	-
L0Y81_RS01250 (L0Y81_01250)	295015..296550	+	1536	WP_249458847.1	multidrug efflux transporter outer membrane subunit OpcM	-
L0Y81_RS01255 (L0Y81_01255)	296729..297079	-	351	WP_105834886.1	type II toxin-antitoxin system ChpB family toxin	Toxin
L0Y81_RS01260 (L0Y81_01260)	297073..297324	-	252	WP_105834901.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
L0Y81_RS01265 (L0Y81_01265)	297877..299370	-	1494	WP_105834887.1	M81 family metallopeptidase	-
L0Y81_RS01270 (L0Y81_01270)	299471..300775	-	1305	WP_039222447.1	MFS transporter	-
L0Y81_RS01275 (L0Y81_01275)	300917..301888	+	972	WP_006397255.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (8-114)

Antitoxin

• SpoVT-AbrB domain (6-49)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12356.39 Da
• Isoelectric Point: 10.4367

>T231703 WP_105834886.1 NZ_CP090717:c297079-296729 [Burkholderia multivorans]
MVKRVKFERGDIVRVSLNPTLGREQQGDFRPALVLSPAAFNALGVALVAPITQGGEFARFAGFAVPLSGAGTATQGVALV
NMVRMLDLEARGARKVERAPVEVVEDALARLQTIIE

Nucleotide

• Length: 351 bp

>T231703 NZ_CP126944:2090144-2090398 [Escherichia coli O1:K1:H7]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTATAGAGGAACACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 8993.33 Da
• Isoelectric Point: 6.2420

>AT231703 WP_105834901.1 NZ_CP090717:c297324-297073 [Burkholderia multivorans]
MELKIQKWGNSAAVRLPSVLLEQINATVGSSLSADVRPDGVLLTPARRKYSLDDLVAQCDTKAPFPADMGAWGEVKPVGR
EAW

Nucleotide

• Length: 252 bp

>AT231703 NZ_CP126944:2089896-2090147 [Escherichia coli O1:K1:H7]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCACCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA