Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 2005122..2005742 Replicon chromosome
Accession NZ_CP090715
Organism Burkholderia multivorans strain 2015Y70629342III

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3KJN2
Locus tag L0Z12_RS25860 Protein ID WP_012217495.1
Coordinates 2005122..2005439 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID B9B269
Locus tag L0Z12_RS25865 Protein ID WP_006398012.1
Coordinates 2005443..2005742 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z12_RS25850 (L0Z12_25850) 2001655..2003088 - 1434 WP_006404214.1 aldehyde dehydrogenase family protein -
L0Z12_RS25855 (L0Z12_25855) 2003117..2004757 - 1641 WP_006398015.1 acetolactate synthase large subunit -
L0Z12_RS25860 (L0Z12_25860) 2005122..2005439 + 318 WP_012217495.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0Z12_RS25865 (L0Z12_25865) 2005443..2005742 + 300 WP_006398012.1 putative addiction module antidote protein Antitoxin
L0Z12_RS25870 (L0Z12_25870) 2005777..2007063 - 1287 WP_053297867.1 DUF445 domain-containing protein -
L0Z12_RS25875 (L0Z12_25875) 2007178..2008398 - 1221 WP_105752934.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
L0Z12_RS25880 (L0Z12_25880) 2008388..2008714 - 327 WP_006404219.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
L0Z12_RS25885 (L0Z12_25885) 2008732..2009220 - 489 WP_006398008.1 anthranilate 1,2-dioxygenase small subunit AndAd -
L0Z12_RS25890 (L0Z12_25890) 2009235..2010506 - 1272 WP_105752935.1 anthranilate 1,2-dioxygenase large subunit AndAc -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-102)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.94 Da        Isoelectric Point: 10.2349

>T231702 WP_012217495.1 NZ_CP090715:2005122-2005439 [Burkholderia multivorans]
MPYLAPTFSIRTTAVFDAWFAGLQDRTAKRRIQARIDRLSMGNLGNWKSVGSPVYEMRIDHGPGYRVYFVRRRTIWVVLL
CGGDKSTQRDDIRAAHAMLEHLDLE

Download         Length: 318 bp

>T231702 NZ_CP126944:2089896-2090147 [Escherichia coli O1:K1:H7]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCACCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10605.00 Da        Isoelectric Point: 6.6381

>AT231702 WP_006398012.1 NZ_CP090715:2005443-2005742 [Burkholderia multivorans]
MSKISTRPWDSAEHLKTDDDMAEYFEACLQEGGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp

>AT231702 NZ_CP126944:2090144-2090398 [Escherichia coli O1:K1:H7]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTATAGAGGAACACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KJN2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3KTI5

References