Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 659244..660514 Replicon chromosome
Accession NZ_CP090715
Organism Burkholderia multivorans strain 2015Y70629342III

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Z12_RS19895 Protein ID WP_105751379.1
Coordinates 659244..659822 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B9BS12
Locus tag L0Z12_RS19900 Protein ID WP_006406126.1
Coordinates 659957..660514 (-) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z12_RS19875 (L0Z12_19875) 654526..655317 + 792 WP_035947285.1 enoyl-CoA hydratase -
L0Z12_RS19880 (L0Z12_19880) 655314..656453 + 1140 WP_006410588.1 enoyl-CoA hydratase/isomerase family protein -
L0Z12_RS19885 (L0Z12_19885) 656500..657420 - 921 WP_065496151.1 LysR family transcriptional regulator -
L0Z12_RS19890 (L0Z12_19890) 657599..659137 + 1539 WP_105751380.1 MFS transporter -
L0Z12_RS19895 (L0Z12_19895) 659244..659822 - 579 WP_105751379.1 HD domain-containing protein Toxin
L0Z12_RS19900 (L0Z12_19900) 659957..660514 - 558 WP_006406126.1 helix-turn-helix transcriptional regulator Antitoxin
L0Z12_RS19905 (L0Z12_19905) 661027..662430 + 1404 WP_088929364.1 hypothetical protein -
L0Z12_RS19910 (L0Z12_19910) 662441..663061 - 621 WP_006410617.1 isochorismatase family cysteine hydrolase -
L0Z12_RS19915 (L0Z12_19915) 663646..664089 - 444 WP_223852633.1 antibiotic biosynthesis monooxygenase -
L0Z12_RS19920 (L0Z12_19920) 664189..665214 - 1026 WP_006406131.1 aldo/keto reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(9-163)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21416.15 Da        Isoelectric Point: 4.9434

>T231697 WP_105751379.1 NZ_CP090715:c659822-659244 [Burkholderia multivorans]
MNPDTIRVRLDFLREAERLKDVLRSGRTSSGRRESTAEHSWRLCLMALVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
ATEQAAHPDKNMHERDDLLTLTAALDPVLRNELVALWDEYDAAASPEARAAKALDKLETILQHTQGANPPDFDYAFNLDY
GRRYTDAAPLFSAIRAIVDADTQRRIDAQAQT

Download         Length: 579 bp

>T231697 NZ_CP126944:188931-189038 [Escherichia coli O1:K1:H7]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20378.30 Da        Isoelectric Point: 7.8341

>AT231697 WP_006406126.1 NZ_CP090715:c660514-659957 [Burkholderia multivorans]
MPDSPLHTPPLGPQLKRWRLLHRVKQSHAAELFGVAQSTISRWEAGVQQMSPDERATAERLLAAHLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPSRAAEFSQPLSMLLGTSLWRYATEEIVRMETALDTLGWHDCAGPPSVEFDTGTNASRVVP
IHRSRCRWTRIMLSDGSAARLVETL

Download         Length: 558 bp

>AT231697 NZ_CP126944:c188874-188817 [Escherichia coli O1:K1:H7]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B9BS12

References