Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 326478..327073 Replicon chromosome
Accession NZ_CP090715
Organism Burkholderia multivorans strain 2015Y70629342III

Toxin (Protein)


Gene name chpB Uniprot ID -
Locus tag L0Z12_RS18455 Protein ID WP_217253156.1
Coordinates 326478..326828 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID B9B2F5
Locus tag L0Z12_RS18460 Protein ID WP_006397258.1
Coordinates 326822..327073 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z12_RS18445 (L0Z12_18445) 321567..324752 + 3186 WP_059786902.1 multidrug efflux RND transporter permease subunit CeoB -
L0Z12_RS18450 (L0Z12_18450) 324763..326298 + 1536 WP_039223192.1 multidrug efflux transporter outer membrane subunit OpcM -
L0Z12_RS18455 (L0Z12_18455) 326478..326828 - 351 WP_217253156.1 type II toxin-antitoxin system ChpB family toxin Toxin
L0Z12_RS18460 (L0Z12_18460) 326822..327073 - 252 WP_006397258.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
L0Z12_RS18465 (L0Z12_18465) 327629..329122 - 1494 WP_217253158.1 M81 family metallopeptidase -
L0Z12_RS18470 (L0Z12_18470) 329223..330527 - 1305 WP_039222447.1 MFS transporter -
L0Z12_RS18475 (L0Z12_18475) 330669..331640 + 972 WP_217253159.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12345.32 Da        Isoelectric Point: 6.3500

>T231696 WP_217253156.1 NZ_CP090715:c326828-326478 [Burkholderia multivorans]
MVKRVKFERGDIVRVSLNPTLGREQQGDFRPALVLSPAAFNALGVALVAPITQGGEFARFAGFAVPLSGAGTETQGVALV
NMVRMLDLEARGARKVESAPVEVVEDALARLQTIIE

Download         Length: 351 bp

>T231696 NZ_CP126944:188448-188555 [Escherichia coli O1:K1:H7]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCACGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9007.36 Da        Isoelectric Point: 6.2420

>AT231696 WP_006397258.1 NZ_CP090715:c327073-326822 [Burkholderia multivorans]
MELKIQKWGNSAAVRLPSVLLEQINATVGSSLSADVRPDGVLLTPARRKYSLDDLVAQCDTKAPFPADMAAWGEVKPVGR
EAW

Download         Length: 252 bp

>AT231696 NZ_CP126944:c188399-188334 [Escherichia coli O1:K1:H7]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A132EKI4

References