Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tad-ata/Tad-HTH_37 |
Location | 2520168..2520868 | Replicon | chromosome |
Accession | NZ_CP090714 | ||
Organism | Burkholderia multivorans strain 2015Y70629342III |
Toxin (Protein)
Gene name | tad | Uniprot ID | A0A8E2RY82 |
Locus tag | L0Z12_RS12120 | Protein ID | WP_070553238.1 |
Coordinates | 2520168..2520545 (+) | Length | 126 a.a. |
Antitoxin (Protein)
Gene name | ata | Uniprot ID | B9BQB8 |
Locus tag | L0Z12_RS12125 | Protein ID | WP_006405635.1 |
Coordinates | 2520545..2520868 (+) | Length | 108 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
L0Z12_RS12095 (L0Z12_12095) | 2515699..2516148 | + | 450 | WP_105751509.1 | VOC family protein | - |
L0Z12_RS12100 (L0Z12_12100) | 2516262..2517812 | - | 1551 | WP_006398698.1 | sodium:solute symporter family protein | - |
L0Z12_RS12105 (L0Z12_12105) | 2517809..2518042 | - | 234 | WP_006398697.1 | DUF3311 domain-containing protein | - |
L0Z12_RS12110 (L0Z12_12110) | 2518239..2519156 | - | 918 | WP_053296988.1 | spermidine synthase | - |
L0Z12_RS12115 (L0Z12_12115) | 2519384..2519638 | + | 255 | WP_059940739.1 | hypothetical protein | - |
L0Z12_RS12120 (L0Z12_12120) | 2520168..2520545 | + | 378 | WP_070553238.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
L0Z12_RS12125 (L0Z12_12125) | 2520545..2520868 | + | 324 | WP_006405635.1 | helix-turn-helix transcriptional regulator | Antitoxin |
L0Z12_RS12130 (L0Z12_12130) | 2520891..2521382 | - | 492 | WP_006398691.1 | DNA-deoxyinosine glycosylase | - |
L0Z12_RS12135 (L0Z12_12135) | 2521379..2521993 | - | 615 | WP_006398690.1 | chorismate lyase | - |
L0Z12_RS12140 (L0Z12_12140) | 2522002..2523900 | - | 1899 | WP_059875776.1 | molecular chaperone HtpG | - |
L0Z12_RS12145 (L0Z12_12145) | 2524059..2525519 | - | 1461 | WP_006405639.1 | PLP-dependent aminotransferase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13507.49 Da Isoelectric Point: 9.3081
>T231695 WP_070553238.1 NZ_CP090714:2520168-2520545 [Burkholderia multivorans]
MGINSSMVPYTKPLYWLGSARKDLKAMPEAVQDTFGYALYLAQTGGKHDQAKPLRGFGSAGVLEVVESEDSGTYRAVYTV
KLGGAVYVLHCFQKKSCRGIATPKPDIELVRARLSAAEAHANGEK
MGINSSMVPYTKPLYWLGSARKDLKAMPEAVQDTFGYALYLAQTGGKHDQAKPLRGFGSAGVLEVVESEDSGTYRAVYTV
KLGGAVYVLHCFQKKSCRGIATPKPDIELVRARLSAAEAHANGEK
Download Length: 378 bp
>T231695 NZ_CP126944:187966-188073 [Escherichia coli O1:K1:H7]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA
Antitoxin
Download Length: 108 a.a. Molecular weight: 11828.69 Da Isoelectric Point: 8.0686
>AT231695 WP_006405635.1 NZ_CP090714:2520545-2520868 [Burkholderia multivorans]
MIEIERGSGNVYADLGTPDAEEMRVKAQLAAKIAEIIKTRKWTQQHAARLLGMTQPKLSNMLRGQFRGVSEAKMLDCLAK
LGRDVQIVVGPDRHSETEGHIEVVFAA
MIEIERGSGNVYADLGTPDAEEMRVKAQLAAKIAEIIKTRKWTQQHAARLLGMTQPKLSNMLRGQFRGVSEAKMLDCLAK
LGRDVQIVVGPDRHSETEGHIEVVFAA
Download Length: 324 bp
>AT231695 NZ_CP126944:c187909-187852 [Escherichia coli O1:K1:H7]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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