231695

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/Tad-HTH_37
Location 2520168..2520868 Replicon chromosome
Accession NZ_CP090714
Organism Burkholderia multivorans strain 2015Y70629342III

Toxin (Protein)


Gene name tad Uniprot ID A0A8E2RY82
Locus tag L0Z12_RS12120 Protein ID WP_070553238.1
Coordinates 2520168..2520545 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID B9BQB8
Locus tag L0Z12_RS12125 Protein ID WP_006405635.1
Coordinates 2520545..2520868 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z12_RS12095 (L0Z12_12095) 2515699..2516148 + 450 WP_105751509.1 VOC family protein -
L0Z12_RS12100 (L0Z12_12100) 2516262..2517812 - 1551 WP_006398698.1 sodium:solute symporter family protein -
L0Z12_RS12105 (L0Z12_12105) 2517809..2518042 - 234 WP_006398697.1 DUF3311 domain-containing protein -
L0Z12_RS12110 (L0Z12_12110) 2518239..2519156 - 918 WP_053296988.1 spermidine synthase -
L0Z12_RS12115 (L0Z12_12115) 2519384..2519638 + 255 WP_059940739.1 hypothetical protein -
L0Z12_RS12120 (L0Z12_12120) 2520168..2520545 + 378 WP_070553238.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0Z12_RS12125 (L0Z12_12125) 2520545..2520868 + 324 WP_006405635.1 helix-turn-helix transcriptional regulator Antitoxin
L0Z12_RS12130 (L0Z12_12130) 2520891..2521382 - 492 WP_006398691.1 DNA-deoxyinosine glycosylase -
L0Z12_RS12135 (L0Z12_12135) 2521379..2521993 - 615 WP_006398690.1 chorismate lyase -
L0Z12_RS12140 (L0Z12_12140) 2522002..2523900 - 1899 WP_059875776.1 molecular chaperone HtpG -
L0Z12_RS12145 (L0Z12_12145) 2524059..2525519 - 1461 WP_006405639.1 PLP-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(22-114)

Antitoxin

Cro/C1-type helix-turn-helix domain

(30-85)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13507.49 Da        Isoelectric Point: 9.3081

>T231695 WP_070553238.1 NZ_CP090714:2520168-2520545 [Burkholderia multivorans]
MGINSSMVPYTKPLYWLGSARKDLKAMPEAVQDTFGYALYLAQTGGKHDQAKPLRGFGSAGVLEVVESEDSGTYRAVYTV
KLGGAVYVLHCFQKKSCRGIATPKPDIELVRARLSAAEAHANGEK

Download         Length: 378 bp

>T231695 NZ_CP126944:187966-188073 [Escherichia coli O1:K1:H7]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11828.69 Da        Isoelectric Point: 8.0686

>AT231695 WP_006405635.1 NZ_CP090714:2520545-2520868 [Burkholderia multivorans]
MIEIERGSGNVYADLGTPDAEEMRVKAQLAAKIAEIIKTRKWTQQHAARLLGMTQPKLSNMLRGQFRGVSEAKMLDCLAK
LGRDVQIVVGPDRHSETEGHIEVVFAA

Download         Length: 324 bp

>AT231695 NZ_CP126944:c187909-187852 [Escherichia coli O1:K1:H7]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B9BQB8

References