Detailed information of TA system TA231692

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 1820779..1822049
• Replicon: chromosome
• Accession: NZ_CP090708
• Organism: Burkholderia multivorans strain 2016Y70836300

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: L0Z15_RS24040
• Protein ID: WP_105751379.1
• Coordinates: 1821471..1822049 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B9BS12
• Locus tag: L0Z15_RS24035
• Protein ID: WP_006406126.1
• Coordinates: 1820779..1821336 (+)
• Length: 186 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z15_RS24015 (L0Z15_24015)	1815841..1816284	+	444	WP_223852633.1	antibiotic biosynthesis monooxygenase	-
L0Z15_RS24020 (L0Z15_24020)	1816838..1818097	-	1260	WP_006401211.1	IS256-like element IS1356 family transposase	-
L0Z15_RS24025 (L0Z15_24025)	1818232..1818852	+	621	WP_006410617.1	isochorismatase family cysteine hydrolase	-
L0Z15_RS24030 (L0Z15_24030)	1818863..1820266	-	1404	WP_088929364.1	hypothetical protein	-
L0Z15_RS24035 (L0Z15_24035)	1820779..1821336	+	558	WP_006406126.1	helix-turn-helix transcriptional regulator	Antitoxin
L0Z15_RS24040 (L0Z15_24040)	1821471..1822049	+	579	WP_105751379.1	HD domain-containing protein	Toxin
L0Z15_RS24045 (L0Z15_24045)	1822156..1823694	-	1539	WP_105751380.1	MFS transporter	-
L0Z15_RS24050 (L0Z15_24050)	1823873..1824793	+	921	WP_065496151.1	LysR family transcriptional regulator	-
L0Z15_RS24055 (L0Z15_24055)	1824840..1825979	-	1140	WP_006410588.1	enoyl-CoA hydratase/isomerase family protein	-
L0Z15_RS24060 (L0Z15_24060)	1825976..1826767	-	792	WP_035947285.1	enoyl-CoA hydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1816838..1818097	1259

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (9-163)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-64)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21416.15 Da
• Isoelectric Point: 4.9434

>T231692 WP_105751379.1 NZ_CP090708:1821471-1822049 [Burkholderia multivorans]
MNPDTIRVRLDFLREAERLKDVLRSGRTSSGRRESTAEHSWRLCLMALVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
ATEQAAHPDKNMHERDDLLTLTAALDPVLRNELVALWDEYDAAASPEARAAKALDKLETILQHTQGANPPDFDYAFNLDY
GRRYTDAAPLFSAIRAIVDADTQRRIDAQAQT

Nucleotide

• Length: 579 bp

>T231692 NZ_CP126943:c82105-81800 [Escherichia coli O1:K1:H7]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGTTGTCAGATAAGGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAGGAAGTG
GCTGATCTCAGCCACCGAGAAAATGACATCAAAAATGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Protein

• Length: 186 a.a.
• Molecular weight: 20378.30 Da
• Isoelectric Point: 7.8341

>AT231692 WP_006406126.1 NZ_CP090708:1820779-1821336 [Burkholderia multivorans]
MPDSPLHTPPLGPQLKRWRLLHRVKQSHAAELFGVAQSTISRWEAGVQQMSPDERATAERLLAAHLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPSRAAEFSQPLSMLLGTSLWRYATEEIVRMETALDTLGWHDCAGPPSVEFDTGTNASRVVP
IHRSRCRWTRIMLSDGSAARLVETL

Nucleotide

• Length: 558 bp

>AT231692 NZ_CP126943:c82325-82107 [Escherichia coli O1:K1:H7]
ATGAAGCAGCGCATTACAGTCACCGTCGACAGTGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGGCT
GGTAAGCACCACCCTGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCAGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGACGAGAACAGGGACTGGTGA

Structures

Antitoxin

• AlphaFold DB: B9BS12