231688

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 1017107..1018146 Replicon chromosome
Accession NZ_CP090708
Organism Burkholderia multivorans strain 2016Y70836300

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag L0Z15_RS20430 Protein ID WP_105751292.1
Coordinates 1017571..1018146 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID A0A8E2S2M5
Locus tag L0Z15_RS20425 Protein ID WP_053298663.1
Coordinates 1017107..1017574 (+) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z15_RS20400 (L0Z15_20400) 1012577..1014040 + 1464 WP_006403683.1 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase -
L0Z15_RS20405 (L0Z15_20405) 1014083..1014931 + 849 WP_105751327.1 3,4-dihydroxyphenylacetate 2,3-dioxygenase -
L0Z15_RS20410 (L0Z15_20410) 1014967..1015359 + 393 WP_105751291.1 5-carboxymethyl-2-hydroxymuconate Delta-isomerase -
L0Z15_RS20415 (L0Z15_20415) 1015374..1016177 + 804 WP_006402377.1 2-oxo-hepta-3-ene-1,7-dioic acid hydratase -
L0Z15_RS20420 (L0Z15_20420) 1016185..1016991 + 807 WP_065495028.1 4-hydroxy-2-oxoheptanedioate aldolase -
L0Z15_RS20425 (L0Z15_20425) 1017107..1017574 + 468 WP_053298663.1 helix-turn-helix domain-containing protein Antitoxin
L0Z15_RS20430 (L0Z15_20430) 1017571..1018146 + 576 WP_105751292.1 PIN domain-containing protein Toxin
L0Z15_RS20435 (L0Z15_20435) 1018391..1019200 - 810 WP_105751293.1 helix-turn-helix transcriptional regulator -
L0Z15_RS20440 (L0Z15_20440) 1019296..1019547 + 252 WP_105751294.1 hypothetical protein -
L0Z15_RS20445 (L0Z15_20445) 1019627..1020592 + 966 WP_105751295.1 zinc-binding alcohol dehydrogenase family protein -
L0Z15_RS20450 (L0Z15_20450) 1020651..1020764 - 114 Protein_923 porin -
L0Z15_RS20455 (L0Z15_20455) 1021116..1021355 + 240 WP_244131642.1 DUF6402 family protein -
L0Z15_RS20460 (L0Z15_20460) 1021352..1021852 + 501 WP_226823143.1 hypothetical protein -
L0Z15_RS20465 (L0Z15_20465) 1021988..1023070 - 1083 WP_105751297.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(10-115)

Antitoxin

Helix-turn-helix domain, group 17

(84-132)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21585.68 Da        Isoelectric Point: 4.8924

>T231688 WP_105751292.1 NZ_CP090708:1017571-1018146 [Burkholderia multivorans]
MTHSPFTAIYDACVLYPAPLRDFLMRLALSGCFRARWSAHITDEWKRNLLDNRPDLTAEQLDRTSSLMDRAIPDAVVTGY
ESLIAGLVLPDADDRHVLTAAIRCNASVIVTFNRKDFPEEALLPYGIEAQHPDEFVDDLFDLEPAVVVAAARRQREALKQ
PPLTADRYLEILRRQGMVQTCQSLDAYRALL

Download         Length: 576 bp

>T231688 NZ_CP126942:c4932672-4932361 [Escherichia coli O1:K1:H7]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17669.09 Da        Isoelectric Point: 5.8709

>AT231688 WP_053298663.1 NZ_CP090708:1017107-1017574 [Burkholderia multivorans]
MHHATTPDMILPVEREMQAAVEAQRMLAAYLATRTDTQRIQIFDDENRAHQVELPTSALRLLVDILAELADGNAVKVVPV
HAELTTQEAADLLNVSRPHLIKLLESNALPYHRTGKHRRVRFSDLMRYKAERDQESADAMEELSKQAQDLRMGYE

Download         Length: 468 bp

>AT231688 NZ_CP126942:c4932360-4932070 [Escherichia coli O1:K1:H7]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References