Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 426921..427541 Replicon chromosome
Accession NZ_CP090708
Organism Burkholderia multivorans strain 2016Y70836300

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3KJN2
Locus tag L0Z15_RS17850 Protein ID WP_012217495.1
Coordinates 427224..427541 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID B9B269
Locus tag L0Z15_RS17845 Protein ID WP_006398012.1
Coordinates 426921..427220 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z15_RS17820 (L0Z15_17820) 422157..423428 + 1272 WP_105752935.1 anthranilate 1,2-dioxygenase large subunit AndAc -
L0Z15_RS17825 (L0Z15_17825) 423443..423931 + 489 WP_006398008.1 anthranilate 1,2-dioxygenase small subunit AndAd -
L0Z15_RS17830 (L0Z15_17830) 423949..424275 + 327 WP_006404219.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
L0Z15_RS17835 (L0Z15_17835) 424265..425485 + 1221 WP_105752934.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
L0Z15_RS17840 (L0Z15_17840) 425600..426886 + 1287 WP_053297867.1 DUF445 domain-containing protein -
L0Z15_RS17845 (L0Z15_17845) 426921..427220 - 300 WP_006398012.1 putative addiction module antidote protein Antitoxin
L0Z15_RS17850 (L0Z15_17850) 427224..427541 - 318 WP_012217495.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0Z15_RS17855 (L0Z15_17855) 427906..429546 + 1641 WP_006398015.1 acetolactate synthase large subunit -
L0Z15_RS17860 (L0Z15_17860) 429575..431008 + 1434 WP_006404214.1 aldehyde dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-102)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.94 Da        Isoelectric Point: 10.2349

>T231687 WP_012217495.1 NZ_CP090708:c427541-427224 [Burkholderia multivorans]
MPYLAPTFSIRTTAVFDAWFAGLQDRTAKRRIQARIDRLSMGNLGNWKSVGSPVYEMRIDHGPGYRVYFVRRRTIWVVLL
CGGDKSTQRDDIRAAHAMLEHLDLE

Download         Length: 318 bp

>T231687 NZ_CP126942:c4626580-4626407 [Escherichia coli O1:K1:H7]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTTCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10605.00 Da        Isoelectric Point: 6.6381

>AT231687 WP_006398012.1 NZ_CP090708:c427220-426921 [Burkholderia multivorans]
MSKISTRPWDSAEHLKTDDDMAEYFEACLQEGGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp

>AT231687 NZ_CP126942:c4626904-4626608 [Escherichia coli O1:K1:H7]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KJN2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3KTI5

References