Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 736557..737190 Replicon chromosome
Accession NZ_CP090707
Organism Burkholderia multivorans strain 2016Y70836300

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Z15_RS03430 Protein ID WP_105767892.1
Coordinates 736777..737190 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L0Z15_RS03425 Protein ID WP_085545763.1
Coordinates 736557..736790 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z15_RS03405 (L0Z15_03405) 732172..733311 + 1140 WP_105751490.1 nucleoside triphosphate pyrophosphohydrolase family protein -
L0Z15_RS03410 (L0Z15_03410) 733308..733970 + 663 WP_105751491.1 uracil-DNA glycosylase -
L0Z15_RS03420 (L0Z15_03420) 735702..736250 - 549 WP_249485854.1 phospholipase D family protein -
L0Z15_RS03425 (L0Z15_03425) 736557..736790 + 234 WP_085545763.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
L0Z15_RS03430 (L0Z15_03430) 736777..737190 + 414 WP_105767892.1 PIN domain-containing protein Toxin
L0Z15_RS03435 (L0Z15_03435) 737225..737587 + 363 WP_105767921.1 DUF3742 family protein -
L0Z15_RS03440 (L0Z15_03440) 737709..738968 - 1260 WP_249458451.1 IS256-like element IS1356 family transposase -
L0Z15_RS03445 (L0Z15_03445) 739033..740466 - 1434 Protein_672 conjugal transfer protein TraG N-terminal domain-containing protein -
L0Z15_RS03450 (L0Z15_03450) 740479..740808 - 330 WP_105767975.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 731542..744771 13229
- inside IScluster/Tn - - 734539..738968 4429


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-120)

Antitoxin

SpoVT-AbrB domain

(5-37)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15293.73 Da        Isoelectric Point: 6.0823

>T231684 WP_105767892.1 NZ_CP090707:736777-737190 [Burkholderia multivorans]
MSGADKAKVFVDSNVVLYLLSGDAAKADRAEALLRRRPTISVQVLNEVTNVCVRKLGMAWREVDQFLELVRQFCVVAPLT
IEMHDLARRIAERYGLAFYDACIVAAASIEGCHALYTEDMHHGLIIEESLTLRNPFA

Download         Length: 414 bp

>T231684 NZ_CP126942:4300346-4300687 [Escherichia coli O1:K1:H7]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGGTTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8732.97 Da        Isoelectric Point: 7.0164

>AT231684 WP_085545763.1 NZ_CP090707:736557-736790 [Burkholderia multivorans]
MQVAKWGNSLAVRLPSSLVEALELREGDDIEIVIDAPRTFAVRKKPGADELLERLRHFRGKLPADFKFSRDEANERG

Download         Length: 234 bp

>AT231684 NZ_CP126942:c4300351-4300275 [Escherichia coli O1:K1:H7]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCAGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References