Detailed information of TA system TA231682

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 1726107..1727377
• Replicon: chromosome
• Accession: NZ_CP090705
• Organism: Burkholderia multivorans strain 2016Y70888756VI

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: L0Z41_RS26135
• Protein ID: WP_105751379.1
• Coordinates: 1726799..1727377 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B9BS12
• Locus tag: L0Z41_RS26130
• Protein ID: WP_006406126.1
• Coordinates: 1726107..1726664 (+)
• Length: 186 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z41_RS26110 (L0Z41_26110)	1721407..1722432	+	1026	WP_006406131.1	aldo/keto reductase	-
L0Z41_RS26115 (L0Z41_26115)	1722532..1722975	+	444	WP_223852633.1	antibiotic biosynthesis monooxygenase	-
L0Z41_RS26120 (L0Z41_26120)	1723560..1724180	+	621	WP_006410617.1	isochorismatase family cysteine hydrolase	-
L0Z41_RS26125 (L0Z41_26125)	1724191..1725594	-	1404	WP_088929364.1	hypothetical protein	-
L0Z41_RS26130 (L0Z41_26130)	1726107..1726664	+	558	WP_006406126.1	helix-turn-helix transcriptional regulator	Antitoxin
L0Z41_RS26135 (L0Z41_26135)	1726799..1727377	+	579	WP_105751379.1	HD domain-containing protein	Toxin
L0Z41_RS26140 (L0Z41_26140)	1727484..1729022	-	1539	WP_105751380.1	MFS transporter	-
L0Z41_RS26145 (L0Z41_26145)	1729201..1730121	+	921	WP_065496151.1	LysR family transcriptional regulator	-
L0Z41_RS26150 (L0Z41_26150)	1730168..1731307	-	1140	WP_006410588.1	enoyl-CoA hydratase/isomerase family protein	-
L0Z41_RS26155 (L0Z41_26155)	1731304..1732095	-	792	WP_035947285.1	enoyl-CoA hydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (9-163)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-64)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21416.15 Da
• Isoelectric Point: 4.9434

>T231682 WP_105751379.1 NZ_CP090705:1726799-1727377 [Burkholderia multivorans]
MNPDTIRVRLDFLREAERLKDVLRSGRTSSGRRESTAEHSWRLCLMALVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
ATEQAAHPDKNMHERDDLLTLTAALDPVLRNELVALWDEYDAAASPEARAAKALDKLETILQHTQGANPPDFDYAFNLDY
GRRYTDAAPLFSAIRAIVDADTQRRIDAQAQT

Nucleotide

• Length: 579 bp

>T231682 NZ_CP126942:c3905792-3905394 [Escherichia coli O1:K1:H7]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGAAGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGTGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGCAGCGCATTTGGTATATTGTCAGGGCGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Protein

• Length: 186 a.a.
• Molecular weight: 20378.30 Da
• Isoelectric Point: 7.8341

>AT231682 WP_006406126.1 NZ_CP090705:1726107-1726664 [Burkholderia multivorans]
MPDSPLHTPPLGPQLKRWRLLHRVKQSHAAELFGVAQSTISRWEAGVQQMSPDERATAERLLAAHLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPSRAAEFSQPLSMLLGTSLWRYATEEIVRMETALDTLGWHDCAGPPSVEFDTGTNASRVVP
IHRSRCRWTRIMLSDGSAARLVETL

Nucleotide

• Length: 558 bp

>AT231682 NZ_CP126942:c3906088-3905795 [Escherichia coli O1:K1:H7]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
TGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTTGAAGCATTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCGAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Structures

Antitoxin

• AlphaFold DB: B9BS12