231680

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1456062..1457809 Replicon chromosome
Accession NZ_CP090705
Organism Burkholderia multivorans strain 2016Y70888756VI

Toxin (Protein)


Gene name doc Uniprot ID B9BHC0
Locus tag L0Z41_RS24935 Protein ID WP_006403210.1
Coordinates 1456913..1457809 (-) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID B9AZJ2
Locus tag L0Z41_RS24930 Protein ID WP_006396780.1
Coordinates 1456062..1456916 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z41_RS24910 (L0Z41_24910) 1451233..1452723 - 1491 WP_088924112.1 aldehyde dehydrogenase -
L0Z41_RS24915 (L0Z41_24915) 1452785..1453615 - 831 WP_006403212.1 aspartate dehydrogenase -
L0Z41_RS24920 (L0Z41_24920) 1453608..1455275 - 1668 WP_053298420.1 thiamine pyrophosphate-binding protein -
L0Z41_RS24925 (L0Z41_24925) 1455268..1456065 - 798 WP_006409174.1 SDR family oxidoreductase -
L0Z41_RS24930 (L0Z41_24930) 1456062..1456916 - 855 WP_006396780.1 IclR family transcriptional regulator Antitoxin
L0Z41_RS24935 (L0Z41_24935) 1456913..1457809 - 897 WP_006403210.1 alpha/beta fold hydrolase Toxin
L0Z41_RS24940 (L0Z41_24940) 1457828..1458355 - 528 WP_006396778.1 cupin domain-containing protein -
L0Z41_RS24945 (L0Z41_24945) 1458383..1459153 - 771 WP_105752056.1 SDR family oxidoreductase -
L0Z41_RS24950 (L0Z41_24950) 1459146..1460216 - 1071 WP_065496357.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
L0Z41_RS24955 (L0Z41_24955) 1460264..1460575 - 312 WP_053298417.1 hypothetical protein -
L0Z41_RS24960 (L0Z41_24960) 1460577..1460894 - 318 WP_053298416.1 non-heme iron oxygenase ferredoxin subunit -
L0Z41_RS24965 (L0Z41_24965) 1461331..1462410 + 1080 WP_006409825.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-280)

Antitoxin

Transcription regulator IclR, N-terminal

(23-71)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30544.80 Da        Isoelectric Point: 8.0446

>T231680 WP_006403210.1 NZ_CP090705:c1457809-1456913 [Burkholderia multivorans]
MSVVDKRERDRTAAFATLLERFPEQRCAAGAAGTIGYREAGAQQAGAALPVVLLHGIGSGAASWVRQLDALGASRRVLAW
DAPGYGASTPVHGASPSAVDYAASLDAWLDALGIARCVLVGHSLGAIVAGGMVRVKPERIAGLLLISPAGGYGSAPAETR
ASRRDARLAMLAELGPAGLAAQRSGNMLSGFATEDARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAGVGLQVIPQAGHAGYVEAPDVYSALIDAFCRQCDIERRAA

Download         Length: 897 bp

>T231680 NZ_CP090705:c1457809-1456913 [Burkholderia multivorans]
ATGAGTGTCGTCGACAAACGAGAACGCGACCGCACCGCGGCGTTCGCCACGCTGCTCGAGCGGTTTCCCGAGCAGCGCTG
CGCCGCCGGCGCGGCGGGCACGATCGGTTATCGCGAGGCCGGTGCGCAGCAGGCTGGCGCCGCGCTGCCCGTCGTGCTGC
TGCACGGGATCGGCTCGGGCGCCGCGTCGTGGGTGCGCCAGCTCGACGCGCTCGGCGCTTCGCGCCGCGTGCTCGCGTGG
GACGCGCCCGGCTACGGCGCATCGACGCCGGTGCACGGCGCATCGCCGTCGGCCGTCGATTATGCGGCGTCGCTCGACGC
GTGGCTCGACGCGCTCGGCATCGCGCGCTGCGTGCTCGTCGGGCATTCGCTCGGCGCGATCGTCGCGGGCGGCATGGTGC
GCGTGAAGCCCGAGCGGATCGCGGGGCTGCTGCTGATTTCGCCGGCCGGCGGTTACGGCAGCGCGCCGGCCGAGACGCGC
GCGTCGCGCCGCGACGCGCGGCTCGCGATGCTCGCGGAACTCGGGCCTGCCGGGCTCGCCGCGCAGCGCAGCGGCAACAT
GCTGTCGGGCTTCGCGACCGAGGACGCGCGCGCATGGGTGCGCTGGAATATGGCGCGCATCGTGCCGGCCGGCTATGCGC
AGGCCACGCATCTGCTCGCCAATGCCGATCTCGCGGCCGATCTCGCCGGGTTCCGCGGCCGCACGGCGGTGGCCGTGGGC
GCGAACGACGCGATTACGCCGCCCGCGGCGTGCGAACGCATCGCGGCGGCCGCCGGCGTCGGACTGCAGGTGATTCCGCA
GGCCGGCCACGCGGGCTACGTCGAGGCGCCCGACGTCTATTCGGCCTTGATCGACGCGTTCTGCCGGCAGTGCGACATCG
AGCGGAGGGCGGCATGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31176.75 Da        Isoelectric Point: 6.6558

>AT231680 WP_006396780.1 NZ_CP090705:c1456916-1456062 [Burkholderia multivorans]
MSEPLQSAAEPAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYKL
GIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSEAPVFSSIRVNVGTRLPAHATTHGHV
LMGDLSLDELRALYPEGTLPRMTNATPDTVDALYTMIREDALRGYGISNSSFERGISVVTAPVRNDTQKIVACITVTVPR
PEIDATLIADGLIDKVRRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 855 bp

>AT231680 NZ_CP090705:c1456916-1456062 [Burkholderia multivorans]
ATGAGCGAACCGTTGCAGAGCGCGGCCGAACCTGCGAAGGCCGAAGCGAGCTACGTCGTGCCCGGCCTCGAGCGCGGGCT
GCGGATTCTCGCCGAATTCTCGCCGCGCGAACCGGTACTCGGCGCGCCGGAGCTGTCGAAGCGGCTCGGCATTCCGCGCA
CGACCGTATTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTTCTCGAGCGCGCCGACAAGGACCGCAACTACAAGCTC
GGCATCGCGGTGCTGCGGCTCGGCTTCGAATATCTGAGCTCGCTCGAGCTGACCGATCTCGGCCTGCCCGTGATCGAAAG
CCTGCGCGATGCGACCGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTCGTGTTCGTTGCGAAGGCGCAGA
GCGAGGCGCCCGTGTTCAGTTCGATTCGCGTGAACGTCGGTACGCGGCTGCCCGCGCACGCGACGACGCACGGTCACGTG
CTGATGGGCGACCTGTCGCTGGACGAGCTGCGCGCGCTGTATCCGGAAGGCACGCTGCCGCGGATGACGAACGCGACGCC
GGACACGGTCGACGCGCTGTACACCATGATCCGCGAGGATGCGCTGCGCGGATACGGCATCAGCAATTCGTCGTTCGAGC
GCGGGATTTCGGTCGTGACCGCGCCGGTGCGCAACGACACGCAGAAGATCGTCGCCTGCATCACGGTGACGGTGCCGCGC
CCGGAGATCGACGCGACGCTGATCGCCGACGGGCTGATCGACAAGGTGCGGCGCGCGGCGGCCGAACTGTCGCGGCGGCT
CAATTACCGCTCGGACGACGAACACACGTTTTTGAAGGCTTTGGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B9BHC0

Antitoxin

Source ID Structure
AlphaFold DB B9AZJ2

References