231678

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 1023451..1024490 Replicon chromosome
Accession NZ_CP090705
Organism Burkholderia multivorans strain 2016Y70888756VI

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag L0Z41_RS23100 Protein ID WP_105751292.1
Coordinates 1023915..1024490 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID A0A8E2S2M5
Locus tag L0Z41_RS23095 Protein ID WP_053298663.1
Coordinates 1023451..1023918 (+) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z41_RS23070 (L0Z41_23070) 1018921..1020384 + 1464 WP_006403683.1 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase -
L0Z41_RS23075 (L0Z41_23075) 1020427..1021275 + 849 WP_105751327.1 3,4-dihydroxyphenylacetate 2,3-dioxygenase -
L0Z41_RS23080 (L0Z41_23080) 1021311..1021703 + 393 WP_105751291.1 5-carboxymethyl-2-hydroxymuconate Delta-isomerase -
L0Z41_RS23085 (L0Z41_23085) 1021718..1022521 + 804 WP_006402377.1 2-oxo-hepta-3-ene-1,7-dioic acid hydratase -
L0Z41_RS23090 (L0Z41_23090) 1022529..1023335 + 807 WP_065495028.1 4-hydroxy-2-oxoheptanedioate aldolase -
L0Z41_RS23095 (L0Z41_23095) 1023451..1023918 + 468 WP_053298663.1 helix-turn-helix domain-containing protein Antitoxin
L0Z41_RS23100 (L0Z41_23100) 1023915..1024490 + 576 WP_105751292.1 PIN domain-containing protein Toxin
L0Z41_RS23105 (L0Z41_23105) 1024735..1025544 - 810 WP_105751293.1 helix-turn-helix transcriptional regulator -
L0Z41_RS23110 (L0Z41_23110) 1025640..1025891 + 252 WP_105751294.1 hypothetical protein -
L0Z41_RS23115 (L0Z41_23115) 1025971..1026936 + 966 WP_105751295.1 zinc-binding alcohol dehydrogenase family protein -
L0Z41_RS23120 (L0Z41_23120) 1026995..1027108 - 114 Protein_937 porin -
L0Z41_RS23125 (L0Z41_23125) 1027460..1027699 + 240 WP_244131642.1 DUF6402 family protein -
L0Z41_RS23130 (L0Z41_23130) 1027696..1028196 + 501 WP_226823143.1 hypothetical protein -
L0Z41_RS23135 (L0Z41_23135) 1028332..1029414 - 1083 WP_105751297.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(10-115)

Antitoxin

Helix-turn-helix domain, group 17

(84-132)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21585.68 Da        Isoelectric Point: 4.8924

>T231678 WP_105751292.1 NZ_CP090705:1023915-1024490 [Burkholderia multivorans]
MTHSPFTAIYDACVLYPAPLRDFLMRLALSGCFRARWSAHITDEWKRNLLDNRPDLTAEQLDRTSSLMDRAIPDAVVTGY
ESLIAGLVLPDADDRHVLTAAIRCNASVIVTFNRKDFPEEALLPYGIEAQHPDEFVDDLFDLEPAVVVAAARRQREALKQ
PPLTADRYLEILRRQGMVQTCQSLDAYRALL

Download         Length: 576 bp

>T231678 NZ_CP126942:2620306-2620584 [Escherichia coli O1:K1:H7]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17669.09 Da        Isoelectric Point: 5.8709

>AT231678 WP_053298663.1 NZ_CP090705:1023451-1023918 [Burkholderia multivorans]
MHHATTPDMILPVEREMQAAVEAQRMLAAYLATRTDTQRIQIFDDENRAHQVELPTSALRLLVDILAELADGNAVKVVPV
HAELTTQEAADLLNVSRPHLIKLLESNALPYHRTGKHRRVRFSDLMRYKAERDQESADAMEELSKQAQDLRMGYE

Download         Length: 468 bp

>AT231678 NZ_CP126942:2620584-2620868 [Escherichia coli O1:K1:H7]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCGGAA
AAAACGGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References