Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1481772..1482349 Replicon chromosome
Accession NZ_CP090702
Organism Burkholderia multivorans strain 2016Y70910410I

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Z36_RS24695 Protein ID WP_053298683.1
Coordinates 1481984..1482349 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L0Z36_RS24690 Protein ID WP_249470790.1
Coordinates 1481772..1481990 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z36_RS24670 (L0Z36_24670) 1477411..1478682 - 1272 WP_053298681.1 Zn-dependent hydrolase -
L0Z36_RS24675 (L0Z36_24675) 1478675..1479214 - 540 WP_006403831.1 L-2-amino-thiazoline-4-carboxylic acid hydrolase -
L0Z36_RS24680 (L0Z36_24680) 1479432..1480598 - 1167 WP_006403832.1 branched-chain amino acid ABC transporter substrate-binding protein -
L0Z36_RS24685 (L0Z36_24685) 1480774..1481670 + 897 WP_035954582.1 LysR substrate-binding domain-containing protein -
L0Z36_RS24690 (L0Z36_24690) 1481772..1481990 + 219 WP_249470790.1 ribbon-helix-helix protein, CopG family Antitoxin
L0Z36_RS24695 (L0Z36_24695) 1481984..1482349 + 366 WP_053298683.1 type II toxin-antitoxin system VapC family toxin Toxin
L0Z36_RS24700 (L0Z36_24700) 1482445..1482633 + 189 WP_200053152.1 hypothetical protein -
L0Z36_RS24705 (L0Z36_24705) 1482672..1482830 - 159 WP_217056924.1 hypothetical protein -
L0Z36_RS24710 (L0Z36_24710) 1483080..1483643 + 564 WP_006399806.1 alkyl hydroperoxide reductase subunit C -
L0Z36_RS24715 (L0Z36_24715) 1483762..1485360 + 1599 WP_006409866.1 alkyl hydroperoxide reductase subunit F -
L0Z36_RS24720 (L0Z36_24720) 1485422..1486150 - 729 WP_190972338.1 hypothetical protein -
L0Z36_RS24725 (L0Z36_24725) 1486274..1487173 - 900 WP_035487807.1 lipid A hydroxylase LpxO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-106)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-40)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13556.55 Da        Isoelectric Point: 5.1515

>T231673 WP_053298683.1 NZ_CP090702:1481984-1482349 [Burkholderia multivorans]
MVKALFDTNILIDYLSGVESARLELGRYDHRAISTITWMEVLVGTTADDEGPIRAWLSSFDVIPLDSTVADRAVTIRKER
RIRLPDAIVWASAQVNGLLLVSRNTKDFPSTEPGIRVPYQI

Download         Length: 366 bp

>T231673 NZ_CP126942:1192415-1192750 [Escherichia coli O1:K1:H7]
ATGGTAAGCCGATACGTACCCGATACGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTCTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8261.41 Da        Isoelectric Point: 4.7640

>AT231673 WP_249470790.1 NZ_CP090702:1481772-1481990 [Burkholderia multivorans]
MSRVLVDLSDGQLDELAVIVETEHRPRAAIIRDAIDAYIALHKRPLTDDVFGLWKDRAVDGLAYQEKLRSEW

Download         Length: 219 bp

>AT231673 NZ_CP126942:1192167-1192415 [Escherichia coli O1:K1:H7]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGGGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References