Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 1307068..1308107 | Replicon | chromosome |
| Accession | NZ_CP090702 | ||
| Organism | Burkholderia multivorans strain 2016Y70910410I | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | L0Z36_RS23980 | Protein ID | WP_217076396.1 |
| Coordinates | 1307068..1307643 (-) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | A0A8B3VE28 |
| Locus tag | L0Z36_RS23985 | Protein ID | WP_035946227.1 |
| Coordinates | 1307640..1308107 (-) | Length | 156 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L0Z36_RS23950 (L0Z36_23950) | 1302493..1302993 | - | 501 | WP_226823143.1 | hypothetical protein | - |
| L0Z36_RS23955 (L0Z36_23955) | 1302990..1304180 | - | 1191 | WP_249470695.1 | DUF6402 family protein | - |
| L0Z36_RS23960 (L0Z36_23960) | 1304450..1304563 | + | 114 | Protein_1118 | porin | - |
| L0Z36_RS23965 (L0Z36_23965) | 1304622..1305587 | - | 966 | WP_105774710.1 | zinc-binding alcohol dehydrogenase family protein | - |
| L0Z36_RS23970 (L0Z36_23970) | 1305667..1305918 | - | 252 | WP_105774709.1 | hypothetical protein | - |
| L0Z36_RS23975 (L0Z36_23975) | 1306014..1306823 | + | 810 | WP_006409450.1 | helix-turn-helix transcriptional regulator | - |
| L0Z36_RS23980 (L0Z36_23980) | 1307068..1307643 | - | 576 | WP_217076396.1 | PIN domain-containing protein | Toxin |
| L0Z36_RS23985 (L0Z36_23985) | 1307640..1308107 | - | 468 | WP_035946227.1 | helix-turn-helix domain-containing protein | Antitoxin |
| L0Z36_RS23990 (L0Z36_23990) | 1308223..1309029 | - | 807 | WP_065495028.1 | 4-hydroxy-2-oxoheptanedioate aldolase | - |
| L0Z36_RS23995 (L0Z36_23995) | 1309037..1309840 | - | 804 | WP_006402377.1 | 2-oxo-hepta-3-ene-1,7-dioic acid hydratase | - |
| L0Z36_RS24000 (L0Z36_24000) | 1309855..1310247 | - | 393 | WP_006409445.1 | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | - |
| L0Z36_RS24005 (L0Z36_24005) | 1310283..1311131 | - | 849 | WP_088929843.1 | 3,4-dihydroxyphenylacetate 2,3-dioxygenase | - |
| L0Z36_RS24010 (L0Z36_24010) | 1311174..1312637 | - | 1464 | WP_249470697.1 | 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21525.67 Da Isoelectric Point: 5.2990
>T231672 WP_217076396.1 NZ_CP090702:c1307643-1307068 [Burkholderia multivorans]
MTHSPFTAIYDACVLYPAPLRDFLMRLALSGCFRARWSAHITDEWKRNLLDNRPDLTAEQLDRTSSLMDRAIPDAVVTGY
ESLIAGLVLPDADDRHVLAAAIRCNASVIVTFNRKDFPEEALLPYGIEAQHPDAFVDDLFDLEPAVVVAAARRRREALKQ
PPLTADRYLEILRRQGMVQTCQSLDAYRALL
MTHSPFTAIYDACVLYPAPLRDFLMRLALSGCFRARWSAHITDEWKRNLLDNRPDLTAEQLDRTSSLMDRAIPDAVVTGY
ESLIAGLVLPDADDRHVLAAAIRCNASVIVTFNRKDFPEEALLPYGIEAQHPDAFVDDLFDLEPAVVVAAARRRREALKQ
PPLTADRYLEILRRQGMVQTCQSLDAYRALL
Download Length: 576 bp
>T231672 NZ_CP126942:1024590-1024997 [Escherichia coli O1:K1:H7]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 156 a.a. Molecular weight: 17655.06 Da Isoelectric Point: 5.8709
>AT231672 WP_035946227.1 NZ_CP090702:c1308107-1307640 [Burkholderia multivorans]
MHHATTPDMILPVEREMQAAVEGQRMLAAYLATRTDTQRIQIFDDENRAHQVELPTSALRLLVDILAELADGNAVKVVPV
HAELTTQEAADLLNVSRPHLIKLLESNALPYHRTGKHRRVRFSDLMRYKAERDQESADAMEELSKQAQDLRMGYE
MHHATTPDMILPVEREMQAAVEGQRMLAAYLATRTDTQRIQIFDDENRAHQVELPTSALRLLVDILAELADGNAVKVVPV
HAELTTQEAADLLNVSRPHLIKLLESNALPYHRTGKHRRVRFSDLMRYKAERDQESADAMEELSKQAQDLRMGYE
Download Length: 468 bp
>AT231672 NZ_CP126942:1024343-1024609 [Escherichia coli O1:K1:H7]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|