Detailed information of TA system TA231670

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 782469..783160
• Replicon: chromosome
• Accession: NZ_CP090702
• Organism: Burkholderia multivorans strain 2016Y70910410I

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: L0Z36_RS21650
• Protein ID: WP_065496260.1
• Coordinates: 782705..783160 (+)
• Length: 152 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: L0Z36_RS21645
• Protein ID: WP_065496259.1
• Coordinates: 782469..782708 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z36_RS21620 (L0Z36_21620)	777530..777673	-	144	WP_006409932.1	hypothetical protein	-
L0Z36_RS21625 (L0Z36_21625)	778262..778465	+	204	WP_006403067.1	hypothetical protein	-
L0Z36_RS21630 (L0Z36_21630)	778479..779162	-	684	WP_006396647.1	Fe2+-dependent dioxygenase	-
L0Z36_RS21635 (L0Z36_21635)	779159..779914	-	756	WP_006403069.1	tetratricopeptide repeat protein	-
L0Z36_RS21640 (L0Z36_21640)	779918..782164	-	2247	WP_006403070.1	TonB-dependent siderophore receptor	-
L0Z36_RS21645 (L0Z36_21645)	782469..782708	+	240	WP_065496259.1	Arc family DNA-binding protein	Antitoxin
L0Z36_RS21650 (L0Z36_21650)	782705..783160	+	456	WP_065496260.1	type II toxin-antitoxin system VapC family toxin	Toxin
L0Z36_RS21655 (L0Z36_21655)	783257..784552	-	1296	WP_035487510.1	aspartate carbamoyltransferase	-
L0Z36_RS21660 (L0Z36_21660)	784785..784919	+	135	WP_006409923.1	entericidin A/B family lipoprotein	-
L0Z36_RS21665 (L0Z36_21665)	785013..785588	-	576	WP_065496261.1	permease	-
L0Z36_RS21670 (L0Z36_21670)	785792..786742	-	951	WP_088929831.1	DMT family transporter	-
L0Z36_RS21675 (L0Z36_21675)	787187..787981	-	795	WP_249472028.1	AraC family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

• Arc-like DNA binding domain (7-46)

Sequences

Toxin

Protein

• Length: 152 a.a.
• Molecular weight: 16209.56 Da
• Isoelectric Point: 7.2060

>T231670 WP_065496260.1 NZ_CP090702:782705-783160 [Burkholderia multivorans]
MILVDTNVISEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFGVAALPEGRRRDWLAQSIEHRVVPVFRGRILPFDD
AASKAYARIRAHARAGGNAIAPADGYIAATAEANGLIVATRDVAPFEAAGLRVIDPWASQGAPVRQGIASK

Nucleotide

• Length: 456 bp

>T231670 NZ_CP126942:c842294-841917 [Escherichia coli O1:K1:H7]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACAATGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8750.96 Da
• Isoelectric Point: 5.1133

>AT231670 WP_065496259.1 NZ_CP090702:782469-782708 [Burkholderia multivorans]
MPVITVRNLPDEVHRALRVRAALHGRSTEAEVRDILEQAVLSEGRVKLGTLLAEIGREAGGVDFDIQRDKTPTDPMSFE

Nucleotide

• Length: 240 bp

>AT231670 NZ_CP126942:c842718-842341 [Escherichia coli O1:K1:H7]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCATCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGATACCCTTGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAATCACCGTATAA