Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 620679..621949 Replicon chromosome
Accession NZ_CP090702
Organism Burkholderia multivorans strain 2016Y70910410I

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Z36_RS20965 Protein ID WP_006410613.1
Coordinates 620679..621257 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L0Z36_RS20970 Protein ID WP_249471917.1
Coordinates 621392..621949 (-) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z36_RS20945 (L0Z36_20945) 615967..616758 + 792 WP_035947285.1 enoyl-CoA hydratase -
L0Z36_RS20950 (L0Z36_20950) 616755..617894 + 1140 WP_006410588.1 enoyl-CoA hydratase/isomerase family protein -
L0Z36_RS20955 (L0Z36_20955) 617941..618861 - 921 WP_105837736.1 LysR family transcriptional regulator -
L0Z36_RS20960 (L0Z36_20960) 619040..620578 + 1539 WP_249471914.1 MFS transporter -
L0Z36_RS20965 (L0Z36_20965) 620679..621257 - 579 WP_006410613.1 HD domain-containing protein Toxin
L0Z36_RS20970 (L0Z36_20970) 621392..621949 - 558 WP_249471917.1 helix-turn-helix transcriptional regulator Antitoxin
L0Z36_RS20975 (L0Z36_20975) 622462..623865 + 1404 WP_088929364.1 hypothetical protein -
L0Z36_RS20980 (L0Z36_20980) 623876..624496 - 621 WP_249471919.1 isochorismatase family cysteine hydrolase -
L0Z36_RS20985 (L0Z36_20985) 624688..625947 - 1260 WP_006400077.1 IS256-like element IS1356 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 624688..625947 1259


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-173)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-53)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21384.10 Da        Isoelectric Point: 4.9434

>T231669 WP_006410613.1 NZ_CP090702:c621257-620679 [Burkholderia multivorans]
MNPDTIRARLDFLREAERLKDVLRSGRTSSGRRESTAEHSWRLCLMALVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
APEQAAHPDKNMHERDDLLTLTAALDPVLRNELVALWDEYDAAASPEARAAKALDKLETILQHTQGANPPDFDYAFNLDY
GRRYTDAAPLFSAIRAIVDADTQRRIDAQAQT

Download         Length: 579 bp

>T231669 NZ_CP126942:188931-189038 [Escherichia coli O1:K1:H7]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20422.31 Da        Isoelectric Point: 7.4862

>AT231669 WP_249471917.1 NZ_CP090702:c621949-621392 [Burkholderia multivorans]
MPDSPLHTPPLGPQLKRWRLLHRVKQSHAAELFGVAQSTISRWEAGVQQMSPDERATDERLLAAHLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPSRAAEFSQPLSMLLGTSLWRYATEEIVRMETALDTLGWHDCAGPPSVEFDTGTNASRVVP
IHRSRCRWTRIMLSDGSAARLVETL

Download         Length: 558 bp

>AT231669 NZ_CP126942:c188874-188817 [Escherichia coli O1:K1:H7]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References