231668

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/Tad-HTH_37
Location 1889432..1890132 Replicon chromosome
Accession NZ_CP090701
Organism Burkholderia multivorans strain 2016Y70910410I

Toxin (Protein)


Gene name tad Uniprot ID A0A8E2RY82
Locus tag L0Z36_RS11285 Protein ID WP_070553238.1
Coordinates 1889432..1889809 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID B9BQB8
Locus tag L0Z36_RS11290 Protein ID WP_006405635.1
Coordinates 1889809..1890132 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z36_RS11260 (L0Z36_11260) 1884977..1885423 + 447 WP_006405630.1 VOC family protein -
L0Z36_RS11265 (L0Z36_11265) 1885526..1887076 - 1551 WP_006398698.1 sodium:solute symporter family protein -
L0Z36_RS11270 (L0Z36_11270) 1887073..1887306 - 234 WP_006398697.1 DUF3311 domain-containing protein -
L0Z36_RS11275 (L0Z36_11275) 1887503..1888420 - 918 WP_088930384.1 spermidine synthase -
L0Z36_RS11280 (L0Z36_11280) 1888648..1888902 + 255 WP_059940739.1 hypothetical protein -
L0Z36_RS11285 (L0Z36_11285) 1889432..1889809 + 378 WP_070553238.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0Z36_RS11290 (L0Z36_11290) 1889809..1890132 + 324 WP_006405635.1 helix-turn-helix transcriptional regulator Antitoxin
L0Z36_RS11295 (L0Z36_11295) 1890155..1890646 - 492 WP_070553236.1 DNA-deoxyinosine glycosylase -
L0Z36_RS11300 (L0Z36_11300) 1890643..1891257 - 615 WP_006398690.1 chorismate lyase -
L0Z36_RS11305 (L0Z36_11305) 1891266..1893164 - 1899 WP_006409758.1 molecular chaperone HtpG -
L0Z36_RS11310 (L0Z36_11310) 1893323..1894783 - 1461 WP_006405639.1 PLP-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(22-114)

Antitoxin

Cro/C1-type helix-turn-helix domain

(30-85)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13507.49 Da        Isoelectric Point: 9.3081

>T231668 WP_070553238.1 NZ_CP090701:1889432-1889809 [Burkholderia multivorans]
MGINSSMVPYTKPLYWLGSARKDLKAMPEAVQDTFGYALYLAQTGGKHDQAKPLRGFGSAGVLEVVESEDSGTYRAVYTV
KLGGAVYVLHCFQKKSCRGIATPKPDIELVRARLSAAEAHANGEK

Download         Length: 378 bp

>T231668 NZ_CP126942:188448-188555 [Escherichia coli O1:K1:H7]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCACGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11828.69 Da        Isoelectric Point: 8.0686

>AT231668 WP_006405635.1 NZ_CP090701:1889809-1890132 [Burkholderia multivorans]
MIEIERGSGNVYADLGTPDAEEMRVKAQLAAKIAEIIKTRKWTQQHAARLLGMTQPKLSNMLRGQFRGVSEAKMLDCLAK
LGRDVQIVVGPDRHSETEGHIEVVFAA

Download         Length: 324 bp

>AT231668 NZ_CP126942:c188399-188334 [Escherichia coli O1:K1:H7]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B9BQB8

References