Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 273650..274287 Replicon chromosome
Accession NZ_CP090701
Organism Burkholderia multivorans strain 2016Y70910410I

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Z36_RS03705 Protein ID WP_217057977.1
Coordinates 273650..274051 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A132EWB1
Locus tag L0Z36_RS03710 Protein ID WP_006408845.1
Coordinates 274051..274287 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z36_RS03695 (L0Z36_03695) 270988..272130 + 1143 WP_070555436.1 alginate lyase family protein -
L0Z36_RS03700 (L0Z36_03700) 272157..273545 + 1389 WP_006408285.1 L-serine ammonia-lyase -
L0Z36_RS03705 (L0Z36_03705) 273650..274051 - 402 WP_217057977.1 type II toxin-antitoxin system VapC family toxin Toxin
L0Z36_RS03710 (L0Z36_03710) 274051..274287 - 237 WP_006408845.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
L0Z36_RS03715 (L0Z36_03715) 274475..276178 + 1704 WP_105810757.1 thiamine pyrophosphate-binding protein -
L0Z36_RS03720 (L0Z36_03720) 276175..277272 + 1098 WP_249469982.1 ADP-heptose--LPS heptosyltransferase -
L0Z36_RS03725 (L0Z36_03725) 277391..278422 - 1032 WP_012212492.1 helix-turn-helix domain-containing protein -
L0Z36_RS03730 (L0Z36_03730) 278593..279135 - 543 WP_088923753.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14991.23 Da        Isoelectric Point: 5.7429

>T231667 WP_217057977.1 NZ_CP090701:c274051-273650 [Burkholderia multivorans]
MPRYMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAVTYAELEYGVTLCANPARERRNLAALIEDIPVAPFDVAAAQA
YGPIREATRERKKDHLDKLIGAHAVSLDVVLVTNNERDFASYPGLRLENWLIG

Download         Length: 402 bp

>T231667 NZ_CP126942:187966-188073 [Escherichia coli O1:K1:H7]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8915.00 Da        Isoelectric Point: 5.8651

>AT231667 WP_006408845.1 NZ_CP090701:c274287-274051 [Burkholderia multivorans]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPARRPLTGVLGKFAKFGPDFMAEGRGDQEQAEREGW

Download         Length: 237 bp

>AT231667 NZ_CP126942:c187909-187852 [Escherichia coli O1:K1:H7]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A132EWB1

References