Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1855645..1856318 Replicon chromosome
Accession NZ_CP090699
Organism Burkholderia cepacia strain 2017Y70952565VI

Toxin (Protein)


Gene name vagD Uniprot ID U2G353
Locus tag L0Z01_RS24475 Protein ID WP_021160096.1
Coordinates 1855645..1856061 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID U2FLJ7
Locus tag L0Z01_RS24480 Protein ID WP_021160097.1
Coordinates 1856058..1856318 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z01_RS24455 (L0Z01_24455) 1851358..1851897 - 540 WP_249452222.1 outer membrane protein assembly factor BamE -
L0Z01_RS24460 (L0Z01_24460) 1852144..1853307 - 1164 WP_027787433.1 M20 aminoacylase family protein -
L0Z01_RS24465 (L0Z01_24465) 1853649..1854722 + 1074 WP_249453548.1 type IV toxin-antitoxin system AbiEi family antitoxin -
L0Z01_RS24470 (L0Z01_24470) 1854691..1855596 + 906 WP_104766674.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
L0Z01_RS24475 (L0Z01_24475) 1855645..1856061 - 417 WP_021160096.1 PIN domain-containing protein Toxin
L0Z01_RS24480 (L0Z01_24480) 1856058..1856318 - 261 WP_021160097.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
L0Z01_RS24485 (L0Z01_24485) 1856569..1857585 - 1017 WP_048020596.1 GNAT family N-acetyltransferase -
L0Z01_RS24490 (L0Z01_24490) 1857585..1858424 - 840 WP_249452223.1 formyltransferase family protein -
L0Z01_RS24495 (L0Z01_24495) 1858511..1860763 - 2253 WP_249452224.1 TonB-dependent siderophore receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14566.75 Da        Isoelectric Point: 7.8895

>T231665 WP_021160096.1 NZ_CP090699:c1856061-1855645 [Burkholderia cepacia]
VTTLYMLDTNICSFIMRERPPVVLSRLQSCVNAQHRIVVSAITYAEMRFGAVGRKASPKHAELVTAFVSRLDGVLSWDTA
AVDATAAIRADLAARGMPIGANDASIAGHAIAAGAVLVTNNGREFGRVAGLSLEDWAA

Download         Length: 417 bp

>T231665 NZ_CP126941:c154857-154708 [Escherichia coli O2:K1:H7]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9546.80 Da        Isoelectric Point: 4.6151

>AT231665 WP_021160097.1 NZ_CP090699:c1856318-1856058 [Burkholderia cepacia]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWLSFASEPLADADFLAERPAVIESGRFDLSGGAA
PTESGQ

Download         Length: 261 bp

>AT231665 NZ_CP126941:154901-154962 [Escherichia coli O2:K1:H7]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U2G353

Antitoxin

Source ID Structure
AlphaFold DB U2FLJ7

References