Detailed information of TA system TA231664

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/Tad-HTH_37
• Location: 951948..952630
• Replicon: chromosome
• Accession: NZ_CP090699
• Organism: Burkholderia cepacia strain 2017Y70952565VI

Toxin (Protein)

• Gene name: tad
• Uniprot ID: A0A2X2PQ15
• Locus tag: L0Z01_RS20160
• Protein ID: WP_048026588.1
• Coordinates: 952268..952630 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: L0Z01_RS20155
• Protein ID: WP_048026590.1
• Coordinates: 951948..952271 (-)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z01_RS20135 (L0Z01_20135)	947333..948793	+	1461	WP_021158544.1	PLP-dependent aminotransferase family protein	-
L0Z01_RS20140 (L0Z01_20140)	948948..950846	+	1899	WP_059590634.1	molecular chaperone HtpG	-
L0Z01_RS20145 (L0Z01_20145)	950855..951454	+	600	WP_042974122.1	chorismate lyase	-
L0Z01_RS20150 (L0Z01_20150)	951454..951930	+	477	WP_249453191.1	DNA-deoxyinosine glycosylase	-
L0Z01_RS20155 (L0Z01_20155)	951948..952271	-	324	WP_048026590.1	helix-turn-helix transcriptional regulator	Antitoxin
L0Z01_RS20160 (L0Z01_20160)	952268..952630	-	363	WP_048026588.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L0Z01_RS20165 (L0Z01_20165)	952954..953208	-	255	WP_021158550.1	hypothetical protein	-
L0Z01_RS20170 (L0Z01_20170)	953352..954269	+	918	WP_021158551.1	spermidine synthase-like protein	-
L0Z01_RS20175 (L0Z01_20175)	954468..954710	+	243	WP_021158552.1	DUF3311 domain-containing protein	-
L0Z01_RS20180 (L0Z01_20180)	954707..956257	+	1551	WP_048026582.1	sodium:solute symporter family protein	-
L0Z01_RS20185 (L0Z01_20185)	956318..956773	-	456	WP_059486351.1	VOC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (16-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (30-85)

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13176.02 Da
• Isoelectric Point: 9.5201

>T231664 WP_048026588.1 NZ_CP090699:c952630-952268 [Burkholderia cepacia]
MDPYIKPLYWLGSALKDLKAMPDAVQDTVGYALYLAQTGRKHDHAKPLRGFGSAGVLEIVESEDNGTYRAVYTVKLGNSV
YVLHSFQKKSSSGIATPKPDVDLIRERLKAAEAHAKGESR

Nucleotide

• Length: 363 bp

>T231664 NZ_CP126941:c151325-151038 [Escherichia coli O2:K1:H7]
ATGACTTATACAGTAAAATTCAGGGATGATGCGCTCAAAGAATGGCTGAAACTGGATAAATCCATTCAACAGCAGTTTGC
GAAAAAACTAAAGAAATGCAGCGAAAATCCTCATATTCCTTCCGCAAAACTGCGTGGATTAAAAGACTGCTACAAAATCA
AACTTCGCGCATCGGGGTTTCGTCTGGTCTATCAGGTTATTGATGACATGCTAATTATTGCGGTTGTCGCGGTAGGTAAA
CGTGAACGTAGTAACGTTTATAATCTCGCCAGTGAGAGAATGAGATAG

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11864.76 Da
• Isoelectric Point: 7.3600

>AT231664 WP_048026590.1 NZ_CP090699:c952271-951948 [Burkholderia cepacia]
MIEIEQGSGNVYADLGRHDADEMLVKAQLAAKIAEIIKARKWTQQHAARLLGMTQPKLSNMLRGQFRGVSETKMIECLAK
LGRDVQIVVGPDRHSEIEGHIEVVFAA

Nucleotide

• Length: 324 bp

>AT231664 NZ_CP126941:c151573-151322 [Escherichia coli O2:K1:H7]
ATGCCTAACATCATTCTGTCTGACACCAGTGCAAGTGTCAGTGAACTGAAAAAAAATCCTATGGCTACAGTCAGTGCCGG
AGATGGTTATCCTGTCGCCATTCTTAACCGGAATCAGCCGGCATTCTACTGTGTGCCTGCGGAACTCTATGAAAGGATGC
TTGATGCGCTGGATGACCAGGAACTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTGCATGATGTGGACCTGGAC
AGTTATTTATGA

Structures

Toxin

• AlphaFold DB: A0A2X2PQ15