Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 2293807..2294453 Replicon chromosome
Accession NZ_CP090698
Organism Burkholderia cepacia strain 2017Y70952565VI

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Z01_RS10090 Protein ID WP_249453716.1
Coordinates 2293807..2294214 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A8E1SEV4
Locus tag L0Z01_RS10095 Protein ID WP_059623347.1
Coordinates 2294211..2294453 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z01_RS10075 (L0Z01_10075) 2290233..2291363 - 1131 WP_249453713.1 porin -
L0Z01_RS10080 (L0Z01_10080) 2291626..2292204 + 579 WP_249453714.1 thioesterase family protein -
L0Z01_RS10085 (L0Z01_10085) 2292223..2293710 + 1488 WP_249453715.1 aldehyde dehydrogenase -
L0Z01_RS10090 (L0Z01_10090) 2293807..2294214 - 408 WP_249453716.1 type II toxin-antitoxin system VapC family toxin Toxin
L0Z01_RS10095 (L0Z01_10095) 2294211..2294453 - 243 WP_059623347.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
L0Z01_RS10100 (L0Z01_10100) 2294713..2295396 + 684 WP_060341578.1 phospholipase -
L0Z01_RS10105 (L0Z01_10105) 2295446..2296957 - 1512 WP_060056156.1 amino acid permease -
L0Z01_RS10110 (L0Z01_10110) 2297064..2298470 - 1407 WP_021161379.1 aspartate ammonia-lyase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14791.93 Da        Isoelectric Point: 5.9816

>T231662 WP_249453716.1 NZ_CP090698:c2294214-2293807 [Burkholderia cepacia]
MKFLLDTNGVIAILKGEPAILSRLRSHQPGGFGIPAIVAHELYYGACKSQRVTANVARVEALQFEVVSFDVEDAQHAGEI
RAHLIAAGTPIGPYDALIAGQARARQLVLITHDIREFERVPGLQVEDWLAEPREN

Download         Length: 408 bp

>T231662 NZ_CP126940:c4920723-4920412 [Escherichia coli O2:K1:H7]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8929.04 Da        Isoelectric Point: 4.7335

>AT231662 WP_059623347.1 NZ_CP090698:c2294453-2294211 [Burkholderia cepacia]
MDIAKIFKHGGSQAVRLPKDFRFDTAEVRIRRHGSSVVLEPVPQDWAWLTPLIGPVDADFEAAATTQPSAQERPDPDVFE

Download         Length: 243 bp

>AT231662 NZ_CP126940:c4920411-4920121 [Escherichia coli O2:K1:H7]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References