Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2238258..2238835 Replicon chromosome
Accession NZ_CP090698
Organism Burkholderia cepacia strain 2017Y70952565VI

Toxin (Protein)


Gene name vapC Uniprot ID A0A8I1DRR3
Locus tag L0Z01_RS09835 Protein ID WP_048026025.1
Coordinates 2238470..2238835 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8B2Q139
Locus tag L0Z01_RS09830 Protein ID WP_048026026.1
Coordinates 2238258..2238476 (+) Length 73 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z01_RS09805 (L0Z01_09805) 2233472..2233954 + 483 WP_249453701.1 GNAT family N-acetyltransferase -
L0Z01_RS09810 (L0Z01_09810) 2234050..2235315 - 1266 WP_048026028.1 Zn-dependent hydrolase -
L0Z01_RS09815 (L0Z01_09815) 2235308..2235832 - 525 WP_021160901.1 L-2-amino-thiazoline-4-carboxylic acid hydrolase -
L0Z01_RS09820 (L0Z01_09820) 2235892..2237058 - 1167 WP_027791290.1 branched-chain amino acid ABC transporter substrate-binding protein -
L0Z01_RS09825 (L0Z01_09825) 2237236..2238132 + 897 WP_048026027.1 LysR substrate-binding domain-containing protein -
L0Z01_RS09830 (L0Z01_09830) 2238258..2238476 + 219 WP_048026026.1 ribbon-helix-helix protein, CopG family Antitoxin
L0Z01_RS09835 (L0Z01_09835) 2238470..2238835 + 366 WP_048026025.1 type II toxin-antitoxin system VapC family toxin Toxin
L0Z01_RS09840 (L0Z01_09840) 2239201..2239764 + 564 WP_006488685.1 alkyl hydroperoxide reductase subunit C -
L0Z01_RS09845 (L0Z01_09845) 2239893..2241491 + 1599 WP_182670402.1 alkyl hydroperoxide reductase subunit F -
L0Z01_RS09850 (L0Z01_09850) 2241670..2242224 - 555 WP_230945234.1 DUF4276 family protein -
L0Z01_RS09855 (L0Z01_09855) 2242260..2243447 - 1188 WP_081057995.1 AAA family ATPase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-106)

Antitoxin

(6-40)


Sequences


Toxin        


Download         Length: 122 a.a.        Molecular weight: 13610.67 Da        Isoelectric Point: 8.4826

>T231661 WP_048026025.1 NZ_CP090698:2238470-2238835 [Burkholderia cepacia]
MVKALFDTNILIDYLGGVESARVELARYSYRAISIISWMEVLVGTSAHDENTTRAWLSSFDVIALDSTIANRAVTIRQER
RIRLPDAIVWASAQVNGLLLVSRNTKDFPATEPGIRMPYRI

Download         Length: 366 bp

>T231661 NZ_CP126940:c4729695-4729147 [Escherichia coli O2:K1:H7]
ATGTCTCACAATTCAGATATCTATAAACTTATCGGAGCGGCCGCAGGTGTTGAAAATGGTCGCTCTGAAGCATCCTTAAA
CTCTACTGACAGTCAAGAACAGATTTTTAAATCTGCATTTGAGCCGTCTAATCATGAGAGCGACGATGATTCTTCTTCAG
AAAATAAAGCTATTCTGGAGGCAGAAGAGTTTGGTTCTAATACTGGTGCATTGCATGAGTTTATGCAGCAGAACAGAATG
GACAGTCTTCAAGCTCAGCTTGATATGCTCAAATCACAAGTACGGGATAAGATAGCTGACGCAACTGGTAAAGAAATAGA
CAATGAGCTTCGGACAAAAATGGCCTCATTCACGGTTTGGTTTATGTCGTGTTGGTGCTTATTCGTTGTCGCAATGTTTA
CATCGTTTCTTATTGCACATGAAGGAAAGCCTCCAGTTGAAGCGATCGTTGCATTACTAGGTACAAGTACAATTAGTATT
GTTGGTTTGGTTGGTTTCGTTGTTAGTGGATTGTTCAAATCAAGAAAAGATAGTGATAAAGAAAAATAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8257.35 Da        Isoelectric Point: 4.4419

>AT231661 WP_048026026.1 NZ_CP090698:2238258-2238476 [Burkholderia cepacia]
MSRILVDLSDGQLDELAAIVETERRPRAAIIRDAIDAYIALHKRPLADDAFGLWKDRTVDGLAYQEEMRSEW

Download         Length: 219 bp

>AT231661 NZ_CP126940:c4730191-4729718 [Escherichia coli O2:K1:H7]
ATGTACAGCCCGGTACAAATAGCCAATAAATTCATAACGTTGGGAAACCAACATCATAATCCTCTGACCCACATGCAACT
GCAGAAGCTTACTTATATTGCACATGGTTACTATTTAGCATTAACAGGTAAGCCTTTGCTCAATGAATGTGTCTCCGCGT
GGAAGTACGGTCCAGTTATTCCTGGAATGTACGATGCTTTCAAAGATTATGGGAATAAACCTGTTACGAATGTAGCAGTA
GCTCCTTTTGGTGGCATTGTTACTATGGATCCACAAGCAGAGAGCATTATAGGGGCTGTTTATAAATTTTACGGCTCGAA
AAATGGAATTGAGTTATCAACTCTAACTCATATGCCTGGTACGCCTTGGTCACAAGCTTATAATGGTATTGGCTCGTCAA
TCATCTCAAATGATGCGATCAAGGCTTATTATCATGATTTATTGAATAACCGACAGCAATGTCAGGGCCTCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A8B2Q139

References