Detailed information of TA system TA231659

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1573743..1574382
• Replicon: chromosome
• Accession: NZ_CP090698
• Organism: Burkholderia cepacia strain 2017Y70952565VI

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: L0Z01_RS06980
• Protein ID: WP_230962748.1
• Coordinates: 1573966..1574382 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: U2G525
• Locus tag: L0Z01_RS06975
• Protein ID: WP_021159426.1
• Coordinates: 1573743..1573979 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z01_RS06955 (L0Z01_06955)	1568843..1569616	+	774	WP_060341252.1	SDR family oxidoreductase	-
L0Z01_RS06960 (L0Z01_06960)	1569687..1570922	-	1236	WP_060341253.1	acyltransferase	-
L0Z01_RS06965 (L0Z01_06965)	1571221..1571964	-	744	WP_249455293.1	methyltransferase domain-containing protein	-
L0Z01_RS06970 (L0Z01_06970)	1572509..1573346	+	838	Protein_1388	hypothetical protein	-
L0Z01_RS06975 (L0Z01_06975)	1573743..1573979	+	237	WP_021159426.1	hypothetical protein	Antitoxin
L0Z01_RS06980 (L0Z01_06980)	1573966..1574382	+	417	WP_230962748.1	type II toxin-antitoxin system VapC family toxin	Toxin
L0Z01_RS06985 (L0Z01_06985)	1574582..1575478	+	897	WP_048025080.1	VOC family protein	-
L0Z01_RS06990 (L0Z01_06990)	1575488..1576381	+	894	WP_042975012.1	CoA-transferase	-
L0Z01_RS06995 (L0Z01_06995)	1576392..1577189	+	798	WP_048025082.1	ketoacid CoA transferase	-
L0Z01_RS07000 (L0Z01_07000)	1577198..1578118	+	921	WP_249455294.1	enoyl-CoA hydratase	-
L0Z01_RS07005 (L0Z01_07005)	1578115..1579215	+	1101	WP_059707397.1	nitronate monooxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15278.57 Da
• Isoelectric Point: 8.5855

>T231659 WP_230962748.1 NZ_CP090698:1573966-1574382 [Burkholderia cepacia]
VYLIDTNVISEIRKGKRTNRGVRAFFRQAAADASPLYLSVVTVAELRRGVDLIRHRGDHPQASALEAWVAMILAGYAPNI
LPVDIEISQTWGHLRVPDPTHELDKLIAATALINDLTVVTRNVADFARTGVRLLNPFD

Nucleotide

• Length: 417 bp

>T231659 NZ_CP126940:4560089-4560466 [Escherichia coli O2:K1:H7]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGATCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAATATTATCCTGGGTAAGCACCCGGAGGTGAAACAATGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8681.75 Da
• Isoelectric Point: 5.8214

>AT231659 WP_021159426.1 NZ_CP090698:1573743-1573979 [Burkholderia cepacia]
MANLLVRNVDDNIVQSLRERAAANGRSAEAEHRAILADALGRPKRKTFAQVLMSMPDVGEDADFQRIQDSGEARRVFD

Nucleotide

• Length: 237 bp

>AT231659 NZ_CP126940:4559632-4560000 [Escherichia coli O2:K1:H7]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGTACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Structures

Antitoxin

• AlphaFold DB: U2G525