Detailed information of TA system TA231657

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1012851..1013506
• Replicon: chromosome
• Accession: NZ_CP090698
• Organism: Burkholderia cepacia strain 2017Y70952565VI

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: L0Z01_RS04495
• Protein ID: WP_249454943.1
• Coordinates: 1013087..1013506 (+)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: U2HMP5
• Locus tag: L0Z01_RS04490
• Protein ID: WP_021158161.1
• Coordinates: 1012851..1013090 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z01_RS04465 (L0Z01_04465)	1008122..1008517	-	396	WP_042973908.1	type II toxin-antitoxin system VapC family toxin	-
L0Z01_RS04470 (L0Z01_04470)	1008514..1008753	-	240	WP_011659184.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
L0Z01_RS04475 (L0Z01_04475)	1008843..1009526	-	684	WP_059650228.1	Fe2+-dependent dioxygenase	-
L0Z01_RS04480 (L0Z01_04480)	1009523..1010290	-	768	WP_249454938.1	tetratricopeptide repeat protein	-
L0Z01_RS04485 (L0Z01_04485)	1010294..1012540	-	2247	WP_249454941.1	TonB-dependent siderophore receptor	-
L0Z01_RS04490 (L0Z01_04490)	1012851..1013090	+	240	WP_021158161.1	antitoxin VapB	Antitoxin
L0Z01_RS04495 (L0Z01_04495)	1013087..1013506	+	420	WP_249454943.1	type II toxin-antitoxin system VapC family toxin	Toxin
L0Z01_RS04500 (L0Z01_04500)	1013642..1014937	-	1296	WP_021158163.1	aspartate carbamoyltransferase	-
L0Z01_RS04505 (L0Z01_04505)	1015171..1015305	+	135	WP_021158165.1	entericidin A/B family lipoprotein	-
L0Z01_RS04510 (L0Z01_04510)	1015400..1015948	-	549	WP_021158166.1	hypothetical protein	-
L0Z01_RS04515 (L0Z01_04515)	1016134..1017087	-	954	WP_249455429.1	DMT family transporter	-
L0Z01_RS04520 (L0Z01_04520)	1017471..1018265	-	795	WP_249454945.1	AraC family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15182.54 Da
• Isoelectric Point: 5.9052

>T231657 WP_249454943.1 NZ_CP090698:1013087-1013506 [Burkholderia cepacia]
MILVDTNVISEPLRREPNAAVIEWLDAQNVETLFLAAISLAEIRLGVAVLPEGRRREWLHQSIEQRVLPLFRGRILPFDD
AASKAYASLRARARAAGVAIAPSDGFIAGAAEANGLIVATRDVTPFEAMGIRVIDPWAR

Nucleotide

• Length: 420 bp

>T231657 NZ_CP126940:c3951603-3951205 [Escherichia coli O2:K1:H7]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGAAGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGTGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGCAGCGCATTTGGTATATTGTCAGGGCGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8629.79 Da
• Isoelectric Point: 5.6643

>AT231657 WP_021158161.1 NZ_CP090698:1012851-1013090 [Burkholderia cepacia]
MPVITVRNLSDEVHRALRIRAAQHGRSTEAEVRDILEQAVLPGGRLKLGTMLAAIGQEAGGFDFDAQRDKTPADPMSFE

Nucleotide

• Length: 240 bp

>AT231657 NZ_CP126940:c3951899-3951606 [Escherichia coli O2:K1:H7]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
TGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTTGAAGCATTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCGAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Structures

Antitoxin

• AlphaFold DB: U2HMP5