Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 857568..858789 Replicon chromosome
Accession NZ_CP090698
Organism Burkholderia cepacia strain 2017Y70952565VI

Toxin (Protein)


Gene name vapC Uniprot ID U2FUP4
Locus tag L0Z01_RS03790 Protein ID WP_021162781.1
Coordinates 857568..858149 (-) Length 194 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A105CX23
Locus tag L0Z01_RS03795 Protein ID WP_059553061.1
Coordinates 858232..858789 (-) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z01_RS03775 (L0Z01_03775) 853237..855297 - 2061 WP_249454842.1 MacB family efflux pump subunit -
L0Z01_RS03780 (L0Z01_03780) 855300..856493 - 1194 WP_249454844.1 macrolide transporter subunit MacA -
L0Z01_RS03785 (L0Z01_03785) 856784..857512 - 729 WP_059812766.1 class I SAM-dependent methyltransferase -
L0Z01_RS03790 (L0Z01_03790) 857568..858149 - 582 WP_021162781.1 HD domain-containing protein Toxin
L0Z01_RS03795 (L0Z01_03795) 858232..858789 - 558 WP_059553061.1 helix-turn-helix transcriptional regulator Antitoxin
L0Z01_RS03800 (L0Z01_03800) 858844..859521 - 678 WP_249481294.1 hypothetical protein -
L0Z01_RS03805 (L0Z01_03805) 859882..861285 + 1404 WP_249454846.1 DUF308 domain-containing protein -
L0Z01_RS03810 (L0Z01_03810) 861382..861960 + 579 WP_021162777.1 hypothetical protein -
L0Z01_RS03815 (L0Z01_03815) 862042..862431 - 390 WP_175892155.1 OsmC family protein -
L0Z01_RS03820 (L0Z01_03820) 862662..863393 + 732 WP_124923717.1 ribonuclease T2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-172)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 194 a.a.        Molecular weight: 21256.86 Da        Isoelectric Point: 5.2812

>T231656 WP_021162781.1 NZ_CP090698:c858149-857568 [Burkholderia cepacia]
MNPDTIHARLAFLREAERLKDVLRSGHTSAGRAESTAEHSWRLCLMALVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSAHERDDLLTLTAPLDPAQRDEIVALWDEYEAAASPEARAAKAFDKLETILQHTQGRNPPGFDYAFNLGY
GRRYTDAAPLFSAIRDIVDADTQRRIDASGQHA

Download         Length: 582 bp

>T231656 NZ_CP126940:3739433-3739651 [Escherichia coli O2:K1:H7]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGTCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20097.06 Da        Isoelectric Point: 10.2051

>AT231656 WP_059553061.1 NZ_CP090698:c858789-858232 [Burkholderia cepacia]
MSASPLHTPPLGPQLKRWRALHRVKQSHAAELFGVAQSTISRWEAGLQQMSPGERATAERLLAARLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPARAAEFSQPLSMLLGTSLWRYATPEIVRMETALDTLGWHDRAGPPSVEFDTGANASRVVP
IRGSLCRWTRMTLSDGSAARLVETL

Download         Length: 558 bp

>AT231656 NZ_CP126940:3739033-3739407 [Escherichia coli O2:K1:H7]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U2FUP4

Antitoxin

Source ID Structure
AlphaFold DB A0A105CX23

References