Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 1832845..1833465 Replicon chromosome
Accession NZ_CP090696
Organism Burkholderia multivorans strain 2017Y71078597II

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3KJN2
Locus tag L0Z09_RS23925 Protein ID WP_012217495.1
Coordinates 1832845..1833162 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID B9B269
Locus tag L0Z09_RS23930 Protein ID WP_006398012.1
Coordinates 1833166..1833465 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z09_RS23915 (L0Z09_23915) 1829378..1830811 - 1434 WP_006404214.1 aldehyde dehydrogenase family protein -
L0Z09_RS23920 (L0Z09_23920) 1830840..1832480 - 1641 WP_006398015.1 acetolactate synthase large subunit -
L0Z09_RS23925 (L0Z09_23925) 1832845..1833162 + 318 WP_012217495.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0Z09_RS23930 (L0Z09_23930) 1833166..1833465 + 300 WP_006398012.1 putative addiction module antidote protein Antitoxin
L0Z09_RS23935 (L0Z09_23935) 1833500..1834786 - 1287 WP_249461891.1 DUF445 domain-containing protein -
L0Z09_RS23940 (L0Z09_23940) 1834901..1836121 - 1221 WP_249461894.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
L0Z09_RS23945 (L0Z09_23945) 1836111..1836437 - 327 WP_006404219.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
L0Z09_RS23950 (L0Z09_23950) 1836455..1836943 - 489 WP_006398008.1 anthranilate 1,2-dioxygenase small subunit AndAd -
L0Z09_RS23955 (L0Z09_23955) 1836958..1838229 - 1272 WP_249461897.1 anthranilate 1,2-dioxygenase large subunit AndAc -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-102)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.94 Da        Isoelectric Point: 10.2349

>T231653 WP_012217495.1 NZ_CP090696:1832845-1833162 [Burkholderia multivorans]
MPYLAPTFSIRTTAVFDAWFAGLQDRTAKRRIQARIDRLSMGNLGNWKSVGSPVYEMRIDHGPGYRVYFVRRRTIWVVLL
CGGDKSTQRDDIRAAHAMLEHLDLE

Download         Length: 318 bp

>T231653 NZ_CP126940:2662836-2663114 [Escherichia coli O2:K1:H7]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10605.00 Da        Isoelectric Point: 6.6381

>AT231653 WP_006398012.1 NZ_CP090696:1833166-1833465 [Burkholderia multivorans]
MSKISTRPWDSAEHLKTDDDMAEYFEACLQEGGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp

>AT231653 NZ_CP126940:2663114-2663398 [Escherichia coli O2:K1:H7]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCGGAA
AAAACGGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KJN2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3KTI5

References