Detailed information of TA system TA231647

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/Tad-HTH_37
• Location: 918606..919306
• Replicon: chromosome
• Accession: NZ_CP090695
• Organism: Burkholderia multivorans strain 2017Y71078597II

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: L0Z09_RS04280
• Protein ID: WP_105801035.1
• Coordinates: 918929..919306 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: B9BQB8
• Locus tag: L0Z09_RS04275
• Protein ID: WP_006405635.1
• Coordinates: 918606..918929 (-)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z09_RS04255 (L0Z09_04255)	913955..915415	+	1461	WP_006405639.1	PLP-dependent aminotransferase family protein	-
L0Z09_RS04260 (L0Z09_04260)	915574..917472	+	1899	WP_059875776.1	molecular chaperone HtpG	-
L0Z09_RS04265 (L0Z09_04265)	917481..918095	+	615	WP_249463432.1	chorismate lyase	-
L0Z09_RS04270 (L0Z09_04270)	918092..918583	+	492	WP_249463437.1	DNA-deoxyinosine glycosylase	-
L0Z09_RS04275 (L0Z09_04275)	918606..918929	-	324	WP_006405635.1	helix-turn-helix transcriptional regulator	Antitoxin
L0Z09_RS04280 (L0Z09_04280)	918929..919306	-	378	WP_105801035.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L0Z09_RS04285 (L0Z09_04285)	919836..920090	-	255	WP_059940739.1	hypothetical protein	-
L0Z09_RS04290 (L0Z09_04290)	920318..921235	+	918	WP_088930384.1	spermidine synthase	-
L0Z09_RS04295 (L0Z09_04295)	921432..921665	+	234	WP_006398697.1	DUF3311 domain-containing protein	-
L0Z09_RS04300 (L0Z09_04300)	921662..923212	+	1551	WP_006398698.1	sodium:solute symporter family protein	-
L0Z09_RS04305 (L0Z09_04305)	923316..923762	-	447	WP_006405630.1	VOC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (23-114)

Antitoxin

• Cro/C1-type helix-turn-helix domain (30-85)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13598.65 Da
• Isoelectric Point: 9.7722

>T231647 WP_105801035.1 NZ_CP090695:c919306-918929 [Burkholderia multivorans]
MGINSSMVPYTKPLYWLGSARKHLKAMPEAVQDTFGYALYLAQTGGKHDQAKPLRGFGSAGVLEVVESEDSGTYRAVYTV
KLGGAVYVLHCFQKKSCRGIATPKPDIELVRARLRAAEAHANGEK

Nucleotide

• Length: 378 bp

>T231647 NZ_CP126940:1122089-1122424 [Escherichia coli O2:K1:H7]
ATGGTAAGCCGATACGTACCCGATACGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTCTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11828.69 Da
• Isoelectric Point: 8.0686

>AT231647 WP_006405635.1 NZ_CP090695:c918929-918606 [Burkholderia multivorans]
MIEIERGSGNVYADLGTPDAEEMRVKAQLAAKIAEIIKTRKWTQQHAARLLGMTQPKLSNMLRGQFRGVSEAKMLDCLAK
LGRDVQIVVGPDRHSETEGHIEVVFAA

Nucleotide

• Length: 324 bp

>AT231647 NZ_CP126940:1121841-1122089 [Escherichia coli O2:K1:H7]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGGGAGCCGAAAGATAAGGAA
GTCTGGTAA

Structures

Antitoxin

• AlphaFold DB: B9BQB8