231646

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 1965283..1965903 Replicon chromosome
Accession NZ_CP090694
Organism Burkholderia multivorans strain 2017Y71079786

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3KJN2
Locus tag L0Y98_RS28495 Protein ID WP_012217495.1
Coordinates 1965283..1965600 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID B9B269
Locus tag L0Y98_RS28500 Protein ID WP_006398012.1
Coordinates 1965604..1965903 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y98_RS28485 (L0Y98_28485) 1961818..1963251 - 1434 WP_039225726.1 aldehyde dehydrogenase family protein -
L0Y98_RS28490 (L0Y98_28490) 1963280..1964920 - 1641 WP_060040466.1 acetolactate synthase large subunit -
L0Y98_RS28495 (L0Y98_28495) 1965283..1965600 + 318 WP_012217495.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0Y98_RS28500 (L0Y98_28500) 1965604..1965903 + 300 WP_006398012.1 putative addiction module antidote protein Antitoxin
L0Y98_RS28505 (L0Y98_28505) 1965938..1967224 - 1287 WP_155824647.1 DUF445 domain-containing protein -
L0Y98_RS28510 (L0Y98_28510) 1967338..1968558 - 1221 WP_155824646.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
L0Y98_RS28515 (L0Y98_28515) 1968548..1968874 - 327 WP_006404219.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
L0Y98_RS28520 (L0Y98_28520) 1968892..1969380 - 489 WP_155824645.1 anthranilate 1,2-dioxygenase small subunit AndAd -
L0Y98_RS28525 (L0Y98_28525) 1969395..1970666 - 1272 WP_039225733.1 anthranilate 1,2-dioxygenase large subunit AndAc -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-102)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.94 Da        Isoelectric Point: 10.2349

>T231646 WP_012217495.1 NZ_CP090694:1965283-1965600 [Burkholderia multivorans]
MPYLAPTFSIRTTAVFDAWFAGLQDRTAKRRIQARIDRLSMGNLGNWKSVGSPVYEMRIDHGPGYRVYFVRRRTIWVVLL
CGGDKSTQRDDIRAAHAMLEHLDLE

Download         Length: 318 bp

>T231646 NZ_CP126940:968146-968553 [Escherichia coli O2:K1:H7]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10605.00 Da        Isoelectric Point: 6.6381

>AT231646 WP_006398012.1 NZ_CP090694:1965604-1965903 [Burkholderia multivorans]
MSKISTRPWDSAEHLKTDDDMAEYFEACLQEGGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp

>AT231646 NZ_CP126940:967899-968165 [Escherichia coli O2:K1:H7]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KJN2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3KTI5

References