Detailed information of TA system TA231645

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 1177891..1178425
• Replicon: chromosome
• Accession: NZ_CP090694
• Organism: Burkholderia multivorans strain 2017Y71079786

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: L0Y98_RS24980
• Protein ID: WP_155825023.1
• Coordinates: 1177891..1178190 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: J4RB90
• Locus tag: L0Y98_RS24985
• Protein ID: WP_006413656.1
• Coordinates: 1178180..1178425 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Y98_RS24965 (L0Y98_24965)	1174240..1175547	+	1308	WP_155825025.1	shikimate transporter	-
L0Y98_RS24970 (L0Y98_24970)	1175582..1176199	-	618	WP_231132780.1	HNH endonuclease	-
L0Y98_RS24975 (L0Y98_24975)	1176481..1177782	+	1302	WP_006403538.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
L0Y98_RS24980 (L0Y98_24980)	1177891..1178190	-	300	WP_155825023.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L0Y98_RS24985 (L0Y98_24985)	1178180..1178425	-	246	WP_006413656.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
L0Y98_RS24990 (L0Y98_24990)	1178565..1179335	+	771	WP_006403543.1	IclR family transcriptional regulator C-terminal domain-containing protein	-
L0Y98_RS24995 (L0Y98_24995)	1179366..1181666	-	2301	WP_155825022.1	ATP-dependent DNA helicase	-
L0Y98_RS25000 (L0Y98_25000)	1181663..1183366	-	1704	WP_155825021.1	VRR-NUC domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-94)

Antitoxin

• Antitoxin ParD (1-80)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11542.04 Da
• Isoelectric Point: 7.3154

>T231645 WP_155825023.1 NZ_CP090694:c1178190-1177891 [Burkholderia multivorans]
MPVKARTVRLTPLAEADLEAIWAYTYERWSLDQAERYIGELSAAFERLARRESVGWPSRAGGNYSRYLVGSHVAFYRETT
ETLDVIRVLHQRMDVDRHL

Nucleotide

• Length: 300 bp

>T231645 NZ_CP126940:c850181-849804 [Escherichia coli O2:K1:H7]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACAATGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8632.71 Da
• Isoelectric Point: 6.4604

>AT231645 WP_006413656.1 NZ_CP090694:c1178425-1178180 [Burkholderia multivorans]
MARNTSISLGDHLAEFVDMQVASGRYGSASDVVRAGLRLLETQETELRALQEALKAGEASGTPAPFDSQAFLARMRAKHA
G

Nucleotide

• Length: 246 bp

>AT231645 NZ_CP126940:c850605-850228 [Escherichia coli O2:K1:H7]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCATCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGATACCCTTGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAATCACCGTATAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3KUX0