231641

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 585044..586334 Replicon chromosome
Accession NZ_CP090694
Organism Burkholderia multivorans strain 2017Y71079786

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Y98_RS22560 Protein ID WP_155825295.1
Coordinates 585044..585655 (-) Length 204 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L0Y98_RS22565 Protein ID WP_155825294.1
Coordinates 585777..586334 (-) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y98_RS22540 (L0Y98_22540) 580371..581162 + 792 WP_155825297.1 enoyl-CoA hydratase -
L0Y98_RS22545 (L0Y98_22545) 581159..582298 + 1140 WP_035955456.1 enoyl-CoA hydratase/isomerase family protein -
L0Y98_RS22550 (L0Y98_22550) 582345..583265 - 921 WP_006406123.1 LysR family transcriptional regulator -
L0Y98_RS22555 (L0Y98_22555) 583444..584982 + 1539 WP_155825296.1 MFS transporter -
L0Y98_RS22560 (L0Y98_22560) 585044..585655 - 612 WP_155825295.1 HD domain-containing protein Toxin
L0Y98_RS22565 (L0Y98_22565) 585777..586334 - 558 WP_155825294.1 helix-turn-helix transcriptional regulator Antitoxin
L0Y98_RS22570 (L0Y98_22570) 586844..588247 + 1404 WP_155825293.1 DUF308 domain-containing protein -
L0Y98_RS22575 (L0Y98_22575) 588588..589319 + 732 WP_060181351.1 ribonuclease T2 -
L0Y98_RS22580 (L0Y98_22580) 589490..590128 - 639 WP_111310988.1 isochorismatase family cysteine hydrolase -
L0Y98_RS22585 (L0Y98_22585) 590257..591273 - 1017 WP_105777694.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-172)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 204 a.a.        Molecular weight: 22575.38 Da        Isoelectric Point: 5.8329

>T231641 WP_155825295.1 NZ_CP090694:c585655-585044 [Burkholderia multivorans]
MNPDTIRARLDFLREAERLKDVLRSGRTSSGRRESTAEHSWRLCLMALVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
ATEQAAHPEKNMHERDDLLTLTAALDPVLRNELVALWDEYDAAASPEARAAKALDKLETILQHAQGANPPDFDYAFNLGY
GRRYTDAAPLFSAIRAIVDADTQRRIDAQAQTSSQTQTHTHRP

Download         Length: 612 bp

>T231641 NZ_CP126938:c124125-123847 [Escherichia coli O2:K1:H4]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGTGTATTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20339.27 Da        Isoelectric Point: 8.1900

>AT231641 WP_155825294.1 NZ_CP090694:c586334-585777 [Burkholderia multivorans]
MPDSPLHTPPLGPQLNRWRLLHRVKQSHAAALFGVAQSTISRWEAGLQQMSPDERATAERLLAARLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPSRAAEFSQPLSMLLGTSLWRYATEEIVRMETALDTLGWHDCAGPPSVEFDTGTNASRVVP
IHRSRCRWTRIMLSDGSAARLVETL

Download         Length: 558 bp

>AT231641 NZ_CP126938:c124394-124125 [Escherichia coli O2:K1:H4]
ATGGCACAGGTTAATATGAGTTTAAGAATTGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTGGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAAGTCGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References