Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 254365..254960 Replicon chromosome
Accession NZ_CP090694
Organism Burkholderia multivorans strain 2017Y71079786

Toxin (Protein)


Gene name chpB Uniprot ID -
Locus tag L0Y98_RS21100 Protein ID WP_105834886.1
Coordinates 254365..254715 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID B9B2F5
Locus tag L0Y98_RS21105 Protein ID WP_006397258.1
Coordinates 254709..254960 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y98_RS21090 (L0Y98_21090) 249454..252639 + 3186 WP_105770400.1 multidrug efflux RND transporter permease subunit CeoB -
L0Y98_RS21095 (L0Y98_21095) 252650..254185 + 1536 WP_039223192.1 multidrug efflux transporter outer membrane subunit OpcM -
L0Y98_RS21100 (L0Y98_21100) 254365..254715 - 351 WP_105834886.1 type II toxin-antitoxin system ChpB family toxin Toxin
L0Y98_RS21105 (L0Y98_21105) 254709..254960 - 252 WP_006397258.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
L0Y98_RS21110 (L0Y98_21110) 255523..257016 - 1494 WP_155825414.1 M81 family metallopeptidase -
L0Y98_RS21115 (L0Y98_21115) 257117..258421 - 1305 WP_039222447.1 MFS transporter -
L0Y98_RS21120 (L0Y98_21120) 258563..259534 + 972 WP_155825412.1 LysR family transcriptional regulator -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-114)

Antitoxin

(6-49)


Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 12356.39 Da        Isoelectric Point: 10.4367

>T231640 WP_105834886.1 NZ_CP090694:c254715-254365 [Burkholderia multivorans]
MVKRVKFERGDIVRVSLNPTLGREQQGDFRPALVLSPAAFNALGVALVAPITQGGEFARFAGFAVPLSGAGTATQGVALV
NMVRMLDLEARGARKVERAPVEVVEDALARLQTIIE

Download         Length: 351 bp

>T231640 NZ_CP126937:c4689983-4689672 [Escherichia coli O2:K1:H4]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9007.36 Da        Isoelectric Point: 6.2420

>AT231640 WP_006397258.1 NZ_CP090694:c254960-254709 [Burkholderia multivorans]
MELKIQKWGNSAAVRLPSVLLEQINATVGSSLSADVRPDGVLLTPARRKYSLDDLVAQCDTKAPFPADMAAWGEVKPVGR
EAW

Download         Length: 252 bp

>AT231640 NZ_CP126937:c4689671-4689381 [Escherichia coli O2:K1:H4]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A132EKI4

References