Detailed information of TA system TA231640

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpSB/PRK09812-ChpS
• Location: 254365..254960
• Replicon: chromosome
• Accession: NZ_CP090694
• Organism: Burkholderia multivorans strain 2017Y71079786

Toxin (Protein)

• Gene name: chpB
• Uniprot ID: -
• Locus tag: L0Y98_RS21100
• Protein ID: WP_105834886.1
• Coordinates: 254365..254715 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: B9B2F5
• Locus tag: L0Y98_RS21105
• Protein ID: WP_006397258.1
• Coordinates: 254709..254960 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Y98_RS21090 (L0Y98_21090)	249454..252639	+	3186	WP_105770400.1	multidrug efflux RND transporter permease subunit CeoB	-
L0Y98_RS21095 (L0Y98_21095)	252650..254185	+	1536	WP_039223192.1	multidrug efflux transporter outer membrane subunit OpcM	-
L0Y98_RS21100 (L0Y98_21100)	254365..254715	-	351	WP_105834886.1	type II toxin-antitoxin system ChpB family toxin	Toxin
L0Y98_RS21105 (L0Y98_21105)	254709..254960	-	252	WP_006397258.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
L0Y98_RS21110 (L0Y98_21110)	255523..257016	-	1494	WP_155825414.1	M81 family metallopeptidase	-
L0Y98_RS21115 (L0Y98_21115)	257117..258421	-	1305	WP_039222447.1	MFS transporter	-
L0Y98_RS21120 (L0Y98_21120)	258563..259534	+	972	WP_155825412.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (8-114)

Antitoxin

• SpoVT-AbrB domain (6-49)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12356.39 Da
• Isoelectric Point: 10.4367

>T231640 WP_105834886.1 NZ_CP090694:c254715-254365 [Burkholderia multivorans]
MVKRVKFERGDIVRVSLNPTLGREQQGDFRPALVLSPAAFNALGVALVAPITQGGEFARFAGFAVPLSGAGTATQGVALV
NMVRMLDLEARGARKVERAPVEVVEDALARLQTIIE

Nucleotide

• Length: 351 bp

>T231640 NZ_CP126937:c4689983-4689672 [Escherichia coli O2:K1:H4]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9007.36 Da
• Isoelectric Point: 6.2420

>AT231640 WP_006397258.1 NZ_CP090694:c254960-254709 [Burkholderia multivorans]
MELKIQKWGNSAAVRLPSVLLEQINATVGSSLSADVRPDGVLLTPARRKYSLDDLVAQCDTKAPFPADMAAWGEVKPVGR
EAW

Nucleotide

• Length: 252 bp

>AT231640 NZ_CP126937:c4689671-4689381 [Escherichia coli O2:K1:H4]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A132EKI4