Detailed information of TA system TA231639

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 3024336..3024892
• Replicon: chromosome
• Accession: NZ_CP090692
• Organism: Burkholderia multivorans strain 2017Y71079786

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: L0Y98_RS14235
• Protein ID: WP_229637027.1
• Coordinates: 3024336..3024587 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M4UBZ0
• Locus tag: L0Y98_RS14240
• Protein ID: WP_004541313.1
• Coordinates: 3024614..3024892 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Y98_RS14215 (L0Y98_14215)	3021816..3022769	+	954	WP_249487140.1	AAA family ATPase	-
L0Y98_RS14220 (L0Y98_14220)	3022811..3023470	-	660	WP_020850627.1	hypothetical protein	-
L0Y98_RS14225 (L0Y98_14225)	3023575..3023823	-	249	WP_004541364.1	hypothetical protein	-
L0Y98_RS30700	3023892..3024026	-	135	WP_258170113.1	hypothetical protein	-
L0Y98_RS14230 (L0Y98_14230)	3024019..3024333	-	315	WP_023872355.1	hypothetical protein	-
L0Y98_RS14235 (L0Y98_14235)	3024336..3024587	-	252	WP_229637027.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L0Y98_RS14240 (L0Y98_14240)	3024614..3024892	-	279	WP_004541313.1	CopG family ribbon-helix-helix protein	Antitoxin
L0Y98_RS14245 (L0Y98_14245)	3024973..3026997	-	2025	WP_023594133.1	relaxase/mobilization nuclease domain-containing protein	-
L0Y98_RS14250 (L0Y98_14250)	3027000..3027269	-	270	WP_020850841.1	plasmid mobilization protein MobA	-
L0Y98_RS14255 (L0Y98_14255)	3027760..3028017	+	258	WP_004541318.1	hypothetical protein	-
L0Y98_RS14260 (L0Y98_14260)	3028095..3028493	+	399	WP_249487090.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	3017988..3030581	12593

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-81)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9580.89 Da
• Isoelectric Point: 9.9718

>T231639 WP_229637027.1 NZ_CP090692:c3024587-3024336 [Burkholderia multivorans]
MQRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLPEQYREWLIDFGDSGYVARYRVDGDTVTILAVRHQKE
AGY

Nucleotide

• Length: 252 bp

>T231639 NZ_CP126937:c4382523-4382350 [Escherichia coli O2:K1:H4]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTTCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10810.11 Da
• Isoelectric Point: 4.9736

>AT231639 WP_004541313.1 NZ_CP090692:c3024892-3024614 [Burkholderia multivorans]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT231639 NZ_CP126937:c4382847-4382551 [Escherichia coli O2:K1:H4]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Antitoxin

• AlphaFold DB: M4UBZ0