Detailed information of TA system TA231638

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/Tad-HTH_37
• Location: 919214..919914
• Replicon: chromosome
• Accession: NZ_CP090692
• Organism: Burkholderia multivorans strain 2017Y71079786

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: L0Y98_RS04335
• Protein ID: WP_155819766.1
• Coordinates: 919537..919914 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: L0Y98_RS04330
• Protein ID: WP_155824476.1
• Coordinates: 919214..919537 (-)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Y98_RS04310 (L0Y98_04310)	914563..916023	+	1461	WP_105780126.1	PLP-dependent aminotransferase family protein	-
L0Y98_RS04315 (L0Y98_04315)	916182..918080	+	1899	WP_039219510.1	molecular chaperone HtpG	-
L0Y98_RS04320 (L0Y98_04320)	918089..918703	+	615	WP_006398690.1	chorismate lyase	-
L0Y98_RS04325 (L0Y98_04325)	918700..919191	+	492	WP_155824623.1	DNA-deoxyinosine glycosylase	-
L0Y98_RS04330 (L0Y98_04330)	919214..919537	-	324	WP_155824476.1	helix-turn-helix transcriptional regulator	Antitoxin
L0Y98_RS04335 (L0Y98_04335)	919537..919914	-	378	WP_155819766.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L0Y98_RS04340 (L0Y98_04340)	920445..920699	-	255	WP_155824475.1	hypothetical protein	-
L0Y98_RS04345 (L0Y98_04345)	920927..921844	+	918	WP_059787259.1	hypothetical protein	-
L0Y98_RS04350 (L0Y98_04350)	922041..922274	+	234	WP_006398697.1	DUF3311 domain-containing protein	-
L0Y98_RS04355 (L0Y98_04355)	922271..923821	+	1551	WP_105777957.1	sodium:solute symporter family protein	-
L0Y98_RS04360 (L0Y98_04360)	923925..924374	-	450	WP_006413500.1	VOC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (22-114)

Antitoxin

• Cro/C1-type helix-turn-helix domain (30-85)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13435.42 Da
• Isoelectric Point: 9.5721

>T231638 WP_155819766.1 NZ_CP090692:c919914-919537 [Burkholderia multivorans]
MGINSSMVPYTKPLYWLGSARKDLKAMPEAVQDTFGYALYLAQTGGKHDQAKPLSGFGSAGVLEVVESEDSGTYRAVYTV
KLGGAVYVLHCFQKKSCRGIATPKPDIELVRARLRAAEAHANGGK

Nucleotide

• Length: 378 bp

>T231638 NZ_CP126937:4147995-4148252 [Escherichia coli O2:K1:H4]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11784.74 Da
• Isoelectric Point: 9.1019

>AT231638 WP_155824476.1 NZ_CP090692:c919537-919214 [Burkholderia multivorans]
MIEIERGSGNVYADLGMPGAEEMRVKAQLAAKIAEIIKTRKWTQQHAARLLGMTQPKLSNMLRGQFRGVSEAKMLDCLAK
LGRDVQIVVGPDRHTEAEGHIEVVFAA

Nucleotide

• Length: 324 bp

>AT231638 NZ_CP126937:4148264-4148809 [Escherichia coli O2:K1:H4]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCGGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCTTTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA