Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 2120573..2121168 Replicon chromosome
Accession NZ_CP090688
Organism Burkholderia multivorans strain 2017Y71087112III

Toxin (Protein)


Gene name chpB Uniprot ID -
Locus tag L0Y89_RS09315 Protein ID WP_105834886.1
Coordinates 2120818..2121168 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID -
Locus tag L0Y89_RS09310 Protein ID WP_105834901.1
Coordinates 2120573..2120824 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y89_RS09295 (L0Y89_09295) 2116009..2116980 - 972 WP_006397255.1 LysR family transcriptional regulator -
L0Y89_RS09300 (L0Y89_09300) 2117122..2118426 + 1305 WP_039222447.1 MFS transporter -
L0Y89_RS09305 (L0Y89_09305) 2118527..2120020 + 1494 WP_105834887.1 M81 family metallopeptidase -
L0Y89_RS09310 (L0Y89_09310) 2120573..2120824 + 252 WP_105834901.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
L0Y89_RS09315 (L0Y89_09315) 2120818..2121168 + 351 WP_105834886.1 type II toxin-antitoxin system ChpB family toxin Toxin
L0Y89_RS09320 (L0Y89_09320) 2121347..2122882 - 1536 WP_249458847.1 multidrug efflux transporter outer membrane subunit OpcM -
L0Y89_RS09325 (L0Y89_09325) 2122893..2126078 - 3186 WP_249458849.1 multidrug efflux RND transporter permease subunit CeoB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12356.39 Da        Isoelectric Point: 10.4367

>T231635 WP_105834886.1 NZ_CP090688:2120818-2121168 [Burkholderia multivorans]
MVKRVKFERGDIVRVSLNPTLGREQQGDFRPALVLSPAAFNALGVALVAPITQGGEFARFAGFAVPLSGAGTATQGVALV
NMVRMLDLEARGARKVERAPVEVVEDALARLQTIIE

Download         Length: 351 bp

>T231635 NZ_CP126937:c3761504-3761106 [Escherichia coli O2:K1:H4]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGAAGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGTGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGCAGCGCATTTGGTATATTGTCAGGGCGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 8993.33 Da        Isoelectric Point: 6.2420

>AT231635 WP_105834901.1 NZ_CP090688:2120573-2120824 [Burkholderia multivorans]
MELKIQKWGNSAAVRLPSVLLEQINATVGSSLSADVRPDGVLLTPARRKYSLDDLVAQCDTKAPFPADMGAWGEVKPVGR
EAW

Download         Length: 252 bp

>AT231635 NZ_CP126937:c3761800-3761507 [Escherichia coli O2:K1:H4]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
TGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTTGAAGCATTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCGAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References