Detailed information of TA system TA231634

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 1791078..1792377
• Replicon: chromosome
• Accession: NZ_CP090688
• Organism: Burkholderia multivorans strain 2017Y71087112III

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: L0Y89_RS07875
• Protein ID: WP_105835289.1
• Coordinates: 1791766..1792377 (+)
• Length: 204 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: L0Y89_RS07870
• Protein ID: WP_039216965.1
• Coordinates: 1791078..1791635 (+)
• Length: 186 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Y89_RS07850 (L0Y89_07850)	1786245..1786841	-	597	WP_244131027.1	Crp/Fnr family transcriptional regulator	-
L0Y89_RS07855 (L0Y89_07855)	1787398..1788030	+	633	WP_105835291.1	isochorismatase family cysteine hydrolase	-
L0Y89_RS07860 (L0Y89_07860)	1788092..1788823	-	732	WP_012216547.1	ribonuclease T2	-
L0Y89_RS07865 (L0Y89_07865)	1789165..1790568	-	1404	WP_006396486.1	hypothetical protein	-
L0Y89_RS07870 (L0Y89_07870)	1791078..1791635	+	558	WP_039216965.1	helix-turn-helix transcriptional regulator	Antitoxin
L0Y89_RS07875 (L0Y89_07875)	1791766..1792377	+	612	WP_105835289.1	HD domain-containing protein	Toxin
L0Y89_RS07880 (L0Y89_07880)	1792437..1793975	-	1539	WP_105810115.1	MFS transporter	-
L0Y89_RS07885 (L0Y89_07885)	1794154..1795074	+	921	WP_006406123.1	LysR family transcriptional regulator	-
L0Y89_RS07890 (L0Y89_07890)	1795121..1796260	-	1140	WP_035955456.1	enoyl-CoA hydratase/isomerase family protein	-
L0Y89_RS07895 (L0Y89_07895)	1796257..1797048	-	792	WP_035955458.1	enoyl-CoA hydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (6-189)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-64)

Sequences

Toxin

Protein

• Length: 204 a.a.
• Molecular weight: 22627.45 Da
• Isoelectric Point: 5.5913

>T231634 WP_105835289.1 NZ_CP090688:1791766-1792377 [Burkholderia multivorans]
MNPDTIRARLDFLREAERLKDVLRSGRTSSGRRESTAEHSWRLCLMVLVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
ATEQAAHPEKNMHERDDLLTLTAALDPVLRDELVALWDEYDAAASPEARAAKALDKLETILQHTQGANPPDFDYAFNLGY
GRRYTDAAPLFSAIRAIVDADTQRRIDAQAQTSSQTQTRTHRA

Nucleotide

• Length: 612 bp

>T231634 NZ_CP126937:3526926-3527144 [Escherichia coli O2:K1:H4]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGTCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 186 a.a.
• Molecular weight: 20377.36 Da
• Isoelectric Point: 8.5509

>AT231634 WP_039216965.1 NZ_CP090688:1791078-1791635 [Burkholderia multivorans]
MPDSPLHTPPLGPQLRRWRLLHRVKQSHAAALFGVAQSTISRWEAGVQQMSPDERATAERLLAARLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPSRAAEFSQPLPMLLGTSLWRYATEEIVRMETALDTLGWHDCAGPPSVEFDTGTNASRVVP
IHRSRCRWTRIMLSDGSAARLVETL

Nucleotide

• Length: 558 bp

>AT231634 NZ_CP126937:3526526-3526900 [Escherichia coli O2:K1:H4]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG