Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1630141..1630832 Replicon chromosome
Accession NZ_CP090688
Organism Burkholderia multivorans strain 2017Y71087112III

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Y89_RS07220 Protein ID WP_065496260.1
Coordinates 1630141..1630596 (-) Length 152 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L0Y89_RS07225 Protein ID WP_065496259.1
Coordinates 1630593..1630832 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y89_RS07195 (L0Y89_07195) 1625188..1625982 + 795 WP_105835364.1 AraC family transcriptional regulator -
L0Y89_RS07200 (L0Y89_07200) 1626574..1627524 + 951 WP_175848493.1 DMT family transporter -
L0Y89_RS07205 (L0Y89_07205) 1627720..1628289 + 570 WP_105835361.1 permease -
L0Y89_RS07210 (L0Y89_07210) 1628382..1628516 - 135 WP_006396654.1 entericidin A/B family lipoprotein -
L0Y89_RS07215 (L0Y89_07215) 1628749..1630044 + 1296 WP_035487510.1 aspartate carbamoyltransferase -
L0Y89_RS07220 (L0Y89_07220) 1630141..1630596 - 456 WP_065496260.1 type II toxin-antitoxin system VapC family toxin Toxin
L0Y89_RS07225 (L0Y89_07225) 1630593..1630832 - 240 WP_065496259.1 Arc family DNA-binding protein Antitoxin
L0Y89_RS07230 (L0Y89_07230) 1631137..1633383 + 2247 WP_012216643.1 TonB-dependent siderophore receptor -
L0Y89_RS07235 (L0Y89_07235) 1633387..1634142 + 756 WP_175848494.1 tetratricopeptide repeat protein -
L0Y89_RS07240 (L0Y89_07240) 1634139..1634822 + 684 WP_105835359.1 Fe2+-dependent dioxygenase -
L0Y89_RS07245 (L0Y89_07245) 1634836..1635039 - 204 WP_006396646.1 hypothetical protein -
L0Y89_RS07250 (L0Y89_07250) 1635628..1635771 + 144 WP_006409932.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-46)


Sequences

Toxin        


Download         Length: 152 a.a.        Molecular weight: 16209.56 Da        Isoelectric Point: 7.2060

>T231633 WP_065496260.1 NZ_CP090688:c1630596-1630141 [Burkholderia multivorans]
MILVDTNVISEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFGVAALPEGRRRDWLAQSIEHRVVPVFRGRILPFDD
AASKAYARIRAHARAGGNAIAPADGYIAATAEANGLIVATRDVAPFEAAGLRVIDPWASQGAPVRQGIASK

Download         Length: 456 bp

>T231633 NZ_CP126937:c3497803-3497501 [Escherichia coli O2:K1:H4]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATTGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8750.96 Da        Isoelectric Point: 5.1133

>AT231633 WP_065496259.1 NZ_CP090688:c1630832-1630593 [Burkholderia multivorans]
MPVITVRNLPDEVHRALRVRAALHGRSTEAEVRDILEQAVLSEGRVKLGTLLAEIGREAGGVDFDIQRDKTPTDPMSFE

Download         Length: 240 bp

>AT231633 NZ_CP126937:c3497465-3497124 [Escherichia coli O2:K1:H4]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References