Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1184841..1185375 Replicon chromosome
Accession NZ_CP090688
Organism Burkholderia multivorans strain 2017Y71087112III

Toxin (Protein)


Gene name parE Uniprot ID A0A1W0YQN7
Locus tag L0Y89_RS05345 Protein ID WP_035954873.1
Coordinates 1185076..1185375 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag L0Y89_RS05340 Protein ID WP_105836542.1
Coordinates 1184841..1185086 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y89_RS05325 (L0Y89_05325) 1179868..1181571 + 1704 WP_105836543.1 VRR-NUC domain-containing protein -
L0Y89_RS05330 (L0Y89_05330) 1181568..1183868 + 2301 WP_175848076.1 ATP-dependent DNA helicase -
L0Y89_RS05335 (L0Y89_05335) 1183931..1184701 - 771 WP_249458891.1 IclR family transcriptional regulator C-terminal domain-containing protein -
L0Y89_RS05340 (L0Y89_05340) 1184841..1185086 + 246 WP_105836542.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
L0Y89_RS05345 (L0Y89_05345) 1185076..1185375 + 300 WP_035954873.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0Y89_RS05350 (L0Y89_05350) 1185483..1186784 - 1302 WP_006413706.1 UDP-N-acetylglucosamine 1-carboxyvinyltransferase -
L0Y89_RS05355 (L0Y89_05355) 1187066..1187683 + 618 WP_006397056.1 HNH endonuclease -
L0Y89_RS05360 (L0Y89_05360) 1187718..1189025 - 1308 WP_039218025.1 shikimate transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-94)

Antitoxin

Antitoxin ParD

(1-80)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11570.09 Da        Isoelectric Point: 7.3154

>T231630 WP_035954873.1 NZ_CP090688:1185076-1185375 [Burkholderia multivorans]
MPVKARTVRLTPLAEADLEAIWAYTYERWSLDQAERYIGELSAAFERLARRESVGWPSRAGGNYSRYLVGSHVVFYRETT
ETLDVIRVLHQRMDVDRHL

Download         Length: 300 bp

>T231630 NZ_CP126937:2460916-2462238 [Escherichia coli O2:K1:H4]
ATGCCTAAACTAGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCTGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGAGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATCCCCGAAGA
TGAAACCGTAATGTGTCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGTTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACTGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAGGGAATAACGCCAACGACGCACATTATCAAATTGCCGATTGGCGAAAT
CAGACAGCCCAATGCGACGCTCGATCTTAGCCAAAGCGTTGATAATGAGTATTACTGTTTGCTGCTGGCGAAAGAACTCG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCAAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGCCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCCGGTATCGCGCAAATTATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTCTTCCAGTGGTTGATTGGCGCAACAGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGGCTCACACCATTTTATGACATCATTTCGGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACGGTCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8648.71 Da        Isoelectric Point: 6.4592

>AT231630 WP_105836542.1 NZ_CP090688:1184841-1185086 [Burkholderia multivorans]
MARNTSISLGDHLTEFVDMQVASGRYGSASDVVRAGLRLLETQETELRALQEALKAGDASGTPAPFDSQAFLARMRAKHA
G

Download         Length: 246 bp

>AT231630 NZ_CP126937:2460650-2460916 [Escherichia coli O2:K1:H4]
ATGATGAGCTTTCAGAAGATCTATAGCCCAATGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAACGGCTGGAC
GCAGAGCGAGTTGGCGAAAAAAATCGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAATCCTAACAATACCTCGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCAAAAAATGCCTCGCCAGAAGCA
ACAGAACAGCAAGATCTGGAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1W0YQN7

Antitoxin

Source ID Structure

References