Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 425011..425631 Replicon chromosome
Accession NZ_CP090688
Organism Burkholderia multivorans strain 2017Y71087112III

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3KJN2
Locus tag L0Y89_RS02005 Protein ID WP_012217495.1
Coordinates 425314..425631 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID B9B269
Locus tag L0Y89_RS02000 Protein ID WP_006398012.1
Coordinates 425011..425310 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y89_RS01975 (L0Y89_01975) 420248..421519 + 1272 WP_105835568.1 anthranilate 1,2-dioxygenase large subunit AndAc -
L0Y89_RS01980 (L0Y89_01980) 421534..422022 + 489 WP_006398008.1 anthranilate 1,2-dioxygenase small subunit AndAd -
L0Y89_RS01985 (L0Y89_01985) 422040..422366 + 327 WP_006404219.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
L0Y89_RS01990 (L0Y89_01990) 422356..423576 + 1221 WP_105835569.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
L0Y89_RS01995 (L0Y89_01995) 423690..424976 + 1287 WP_039225729.1 DUF445 domain-containing protein -
L0Y89_RS02000 (L0Y89_02000) 425011..425310 - 300 WP_006398012.1 putative addiction module antidote protein Antitoxin
L0Y89_RS02005 (L0Y89_02005) 425314..425631 - 318 WP_012217495.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0Y89_RS02010 (L0Y89_02010) 425994..427634 + 1641 WP_006398015.1 acetolactate synthase large subunit -
L0Y89_RS02015 (L0Y89_02015) 427663..429096 + 1434 WP_105771374.1 aldehyde dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-102)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.94 Da        Isoelectric Point: 10.2349

>T231628 WP_012217495.1 NZ_CP090688:c425631-425314 [Burkholderia multivorans]
MPYLAPTFSIRTTAVFDAWFAGLQDRTAKRRIQARIDRLSMGNLGNWKSVGSPVYEMRIDHGPGYRVYFVRRRTIWVVLL
CGGDKSTQRDDIRAAHAMLEHLDLE

Download         Length: 318 bp

>T231628 NZ_CP126937:c1995931-1995557 [Escherichia coli O2:K1:H4]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10605.00 Da        Isoelectric Point: 6.6381

>AT231628 WP_006398012.1 NZ_CP090688:c425310-425011 [Burkholderia multivorans]
MSKISTRPWDSAEHLKTDDDMAEYFEACLQEGGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp

>AT231628 NZ_CP126937:c1996388-1996020 [Escherichia coli O2:K1:H4]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KJN2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3KTI5

References